BAIT
WNT3A
wingless-type MMTV integration site family, member 3A
GO Process (63)
GO Function (5)
GO Component (2)
Gene Ontology Biological Process
- COP9 signalosome assembly [ISO]
- Wnt signaling pathway [IBA, ISO]
- Wnt signaling pathway involved in forebrain neuroblast division [ISO]
- anterior/posterior pattern specification [ISO]
- axis elongation involved in somitogenesis [ISO]
- axon guidance [ISO]
- axonogenesis [ISO]
- canonical Wnt signaling pathway [ISO]
- canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment [ISO]
- cardiac muscle cell fate commitment [ISO]
- cell fate commitment [IBA]
- cell proliferation in forebrain [ISO]
- cellular protein localization [ISO]
- determination of left/right symmetry [ISO]
- dorsal/ventral neural tube patterning [ISO]
- extracellular matrix organization [ISO]
- heart looping [ISO]
- hemopoiesis [ISO]
- hippocampus development [ISO]
- in utero embryonic development [ISO]
- inner ear morphogenesis [ISO]
- mammary gland development [ISO]
- mesoderm development [ISO]
- negative regulation of axon extension involved in axon guidance [ISO]
- negative regulation of fat cell differentiation [ISO]
- negative regulation of heart induction by canonical Wnt signaling pathway [ISO]
- negative regulation of neurogenesis [ISO]
- negative regulation of neuron projection development [ISO]
- neuron differentiation [IBA]
- osteoblast differentiation [ISO]
- palate development [ISO]
- paraxial mesodermal cell fate commitment [ISO]
- platelet activation [ISO]
- platelet aggregation [ISO]
- positive regulation of B cell proliferation [ISO]
- positive regulation of canonical Wnt signaling pathway [ISO]
- positive regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation [ISO]
- positive regulation of cardiac muscle cell differentiation [ISO]
- positive regulation of catenin import into nucleus [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of cell-cell adhesion mediated by cadherin [ISO]
- positive regulation of collateral sprouting in absence of injury [ISO]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- positive regulation of cytokine production [ISO]
- positive regulation of dermatome development [ISO]
- positive regulation of mesodermal cell fate specification [ISO]
- positive regulation of neural precursor cell proliferation [ISO]
- positive regulation of peptidyl-serine phosphorylation [ISO]
- positive regulation of protein binding [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of protein tyrosine kinase activity [ISO]
- positive regulation of receptor internalization [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- post-anal tail morphogenesis [ISO]
- regulation of axonogenesis [ISO]
- regulation of cell differentiation [ISO]
- regulation of microtubule cytoskeleton organization [ISO]
- skeletal muscle cell differentiation [ISO]
- somatic stem cell division [ISO]
- somitogenesis [ISO]
- spinal cord association neuron differentiation [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
LRP6
low density lipoprotein receptor-related protein 6
GO Process (93)
GO Function (12)
GO Component (11)
Gene Ontology Biological Process
- Wnt signaling pathway [ISO]
- Wnt signaling pathway involved in dorsal/ventral axis specification [IBA, ISO]
- Wnt signaling pathway involved in forebrain neuroblast division [ISO]
- Wnt signaling pathway involved in somitogenesis [IBA, ISO]
- anterior/posterior pattern specification [IBA, ISO]
- axis elongation [ISO]
- axis elongation involved in somitogenesis [IBA, ISO]
- bone morphogenesis [IBA, ISO]
- bone remodeling [IBA, ISO]
- branching involved in mammary gland duct morphogenesis [IBA, ISO]
- canonical Wnt signaling pathway [IMP, ISO]
- canonical Wnt signaling pathway involved in cardiac neural crest cell differentiation involved in heart development [ISO]
- canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation [ISO]
- cell migration involved in gastrulation [ISO]
- cellular response to cholesterol [ISO]
- cerebellum morphogenesis [IBA, ISO]
- cerebral cortex cell migration [ISO]
- cerebral cortex development [IBA, ISO]
- convergent extension [IBA, ISO]
- dopaminergic neuron differentiation [ISO]
- dorsal/ventral axis specification [ISO]
- embryonic camera-type eye morphogenesis [IBA, ISO]
- embryonic digit morphogenesis [ISO]
- embryonic forelimb morphogenesis [ISO]
- embryonic hindlimb morphogenesis [ISO]
- embryonic limb morphogenesis [IBA, ISO]
- embryonic pattern specification [IBA, ISO]
- embryonic retina morphogenesis in camera-type eye [IBA, ISO]
- external genitalia morphogenesis [IBA, ISO]
- face morphogenesis [IBA, ISO]
- forebrain development [ISO]
- forebrain generation of neurons [ISO]
- forebrain radial glial cell differentiation [ISO]
- formation of radial glial scaffolds [ISO]
- gastrulation with mouth forming second [IBA, ISO]
- generation of neurons [ISO]
- heart looping [ISO]
- limb morphogenesis [ISO]
- mammary gland duct morphogenesis [ISO]
- mammary placode formation [ISO]
- midbrain development [IBA, ISO]
- midbrain-hindbrain boundary development [IBA, ISO]
- morphogenesis of an epithelium [ISO]
- negative regulation of Wnt signaling pathway [ISO]
- negative regulation of epithelial cell proliferation [ISO]
- negative regulation of fat cell differentiation [ISO]
- negative regulation of non-canonical Wnt signaling pathway [ISO]
- negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis [ISO]
- negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis [ISO]
- negative regulation of planar cell polarity pathway involved in neural tube closure [ISO]
- negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis [ISO]
- negative regulation of planar cell polarity pathway involved in pericardium morphogenesis [ISO]
- negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis [ISO]
- negative regulation of protein kinase activity [ISO]
- negative regulation of protein phosphorylation [ISO]
- negative regulation of protein serine/threonine kinase activity [ISO]
- negative regulation of smooth muscle cell apoptotic process [ISO]
- neural crest cell differentiation [IBA, ISO]
- neural crest formation [IBA, ISO]
- neural tube closure [IBA, ISO]
- neural tube development [ISO]
- odontogenesis of dentin-containing tooth [IBA, ISO]
- palate development [IBA, ISO]
- pericardium morphogenesis [IBA, ISO]
- positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of bone resorption [ISO]
- positive regulation of canonical Wnt signaling pathway [ISO]
- positive regulation of cell cycle [ISO]
- positive regulation of cytosolic calcium ion concentration [IMP]
- positive regulation of mesenchymal cell proliferation [ISO]
- positive regulation of ossification [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [IBA, ISO]
- positive regulation of transcription from RNA polymerase II promoter [IBA, ISO]
- positive regulation of transcription, DNA-templated [ISO]
- post-anal tail morphogenesis [ISO]
- primitive streak formation [IBA, ISO]
- receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport [IBA, ISO]
- regulation of cell development [ISO]
- regulation of cell proliferation [ISO]
- regulation of fat cell differentiation [IBA]
- regulation of ossification [IBA]
- regulation of transcription, DNA-templated [IMP]
- response to folic acid [ISO]
- response to peptide hormone [IEP]
- retina morphogenesis in camera-type eye [ISO]
- single organismal cell-cell adhesion [IMP]
- skeletal system morphogenesis [ISO]
- somitogenesis [ISO]
- synaptic transmission [IMP]
- thalamus development [IBA, ISO]
- toxin transport [ISO]
- trachea cartilage morphogenesis [IBA, ISO]
Gene Ontology Molecular Function- Wnt-activated receptor activity [IBA]
- Wnt-protein binding [IBA, ISO]
- apolipoprotein binding [IBA, ISO]
- coreceptor activity [IBA]
- coreceptor activity involved in Wnt signaling pathway [ISO]
- frizzled binding [ISO]
- identical protein binding [ISO]
- kinase inhibitor activity [ISO]
- low-density lipoprotein receptor activity [IBA, ISO]
- protein homodimerization activity [ISO]
- receptor binding [ISO]
- toxin transporter activity [ISO]
- Wnt-activated receptor activity [IBA]
- Wnt-protein binding [IBA, ISO]
- apolipoprotein binding [IBA, ISO]
- coreceptor activity [IBA]
- coreceptor activity involved in Wnt signaling pathway [ISO]
- frizzled binding [ISO]
- identical protein binding [ISO]
- kinase inhibitor activity [ISO]
- low-density lipoprotein receptor activity [IBA, ISO]
- protein homodimerization activity [ISO]
- receptor binding [ISO]
- toxin transporter activity [ISO]
Gene Ontology Cellular Component
Rattus norvegicus
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Wnt proteins induce dishevelled phosphorylation via an LRP5/6- independent mechanism, irrespective of their ability to stabilize beta-catenin.
Wnt glycoproteins play essential roles in the development of metazoan organisms. Many Wnt proteins, such as Wnt1, activate the well-conserved canonical Wnt signaling pathway, which results in accumulation of beta-catenin in the cytosol and nucleus. Other Wnts, such as Wnt5a, activate signaling mechanisms which do not involve beta-catenin and are less well characterized. Dishevelled (Dvl) is a key component of ... [more]
Mol. Cell. Biol. Jun. 01, 2004; 24(11);4757-68 [Pubmed: 15143170]
Throughput
- Low Throughput
Ontology Terms
- phenotype: abnormal protein level (MP:0008469)
Additional Notes
- expression of an LRP5 or LRP6 dominant negative mutant inhibits the activation of beta-catenin induced by expression of Wnt1
Curated By
- BioGRID