BAIT
WNT3A
Wnt-3a, vt, RP23-378H5.2
wingless-type MMTV integration site family, member 3A
GO Process (66)
GO Function (7)
GO Component (2)
Gene Ontology Biological Process
- BMP signaling pathway [ISO]
- COP9 signalosome assembly [IDA]
- Wnt signaling pathway [IGI]
- Wnt signaling pathway involved in forebrain neuroblast division [IMP]
- anterior/posterior pattern specification [IDA]
- axis elongation involved in somitogenesis [IGI]
- axon guidance [IDA]
- axonogenesis [IDA, IGI]
- canonical Wnt signaling pathway [IDA, IGI, IMP, ISO]
- canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment [ISO]
- cardiac muscle cell fate commitment [IGI]
- cell proliferation in forebrain [IDA]
- cell-cell signaling [TAS]
- cellular protein localization [IDA]
- determination of left/right symmetry [IMP]
- dorsal/ventral neural tube patterning [IMP]
- extracellular matrix organization [IDA]
- heart looping [IMP]
- hemopoiesis [IDA]
- hippocampus development [IMP]
- in utero embryonic development [IMP]
- inner ear morphogenesis [IGI]
- mammary gland development [IDA]
- mesoderm development [IMP]
- negative regulation of axon extension involved in axon guidance [IDA]
- negative regulation of fat cell differentiation [IDA, IGI]
- negative regulation of heart induction by canonical Wnt signaling pathway [ISO]
- negative regulation of neurogenesis [IDA]
- negative regulation of neuron projection development [IDA]
- organ morphogenesis [TAS]
- osteoblast differentiation [IGI]
- palate development [ISO]
- paraxial mesodermal cell fate commitment [IMP]
- platelet activation [IDA]
- platelet aggregation [IDA]
- positive regulation of B cell proliferation [IDA]
- positive regulation of canonical Wnt signaling pathway [IDA, ISO]
- positive regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation [IDA]
- positive regulation of cardiac muscle cell differentiation [ISO]
- positive regulation of catenin import into nucleus [ISO]
- positive regulation of cell proliferation [IDA]
- positive regulation of cell-cell adhesion mediated by cadherin [IDA]
- positive regulation of collateral sprouting in absence of injury [IDA]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- positive regulation of cytokine production [IDA]
- positive regulation of dermatome development [ISO]
- positive regulation of mesodermal cell fate specification [ISO]
- positive regulation of neural precursor cell proliferation [IDA]
- positive regulation of peptidyl-serine phosphorylation [ISO]
- positive regulation of protein binding [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of protein tyrosine kinase activity [IGI]
- positive regulation of receptor activity [ISO]
- positive regulation of receptor internalization [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, ISO]
- positive regulation of transcription, DNA-templated [IDA]
- post-anal tail morphogenesis [IMP]
- regulation of axonogenesis [IGI]
- regulation of cell differentiation [IDA]
- regulation of microtubule cytoskeleton organization [IGI]
- signal transduction [TAS]
- skeletal muscle cell differentiation [IGI]
- somatic stem cell division [IDA]
- somitogenesis [IMP]
- spinal cord association neuron differentiation [IDA, IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
DKK1
mdkk-1
dickkopf homolog 1 (Xenopus laevis)
GO Process (28)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
- Wnt signaling pathway involved in somitogenesis [IGI]
- cell morphogenesis involved in differentiation [IMP]
- embryonic limb morphogenesis [IGI]
- endoderm development [IMP]
- endoderm formation [IDA]
- extracellular negative regulation of signal transduction [ISO]
- face morphogenesis [IMP]
- forebrain development [IGI]
- hair follicle development [IDA]
- head morphogenesis [IGI]
- mesoderm formation [IDA]
- negative regulation of BMP signaling pathway [IDA]
- negative regulation of Wnt signaling pathway [IDA, ISO]
- negative regulation of canonical Wnt signaling pathway [IDA, IGI, IMP, ISO]
- negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment [ISO]
- negative regulation of cardiac muscle cell differentiation [ISO]
- negative regulation of mesodermal cell fate specification [ISO]
- negative regulation of pathway-restricted SMAD protein phosphorylation [ISO]
- negative regulation of peptidyl-serine phosphorylation [ISO]
- negative regulation of protein complex assembly [ISO]
- negative regulation of receptor activity [ISO]
- negative regulation of skeletal muscle tissue development [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway [IDA]
- regulation of Wnt signaling pathway [IMP]
- regulation of endodermal cell fate specification [ISO]
- regulation of receptor internalization [ISO]
- response to retinoic acid [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Wnt proteins induce dishevelled phosphorylation via an LRP5/6- independent mechanism, irrespective of their ability to stabilize beta-catenin.
Wnt glycoproteins play essential roles in the development of metazoan organisms. Many Wnt proteins, such as Wnt1, activate the well-conserved canonical Wnt signaling pathway, which results in accumulation of beta-catenin in the cytosol and nucleus. Other Wnts, such as Wnt5a, activate signaling mechanisms which do not involve beta-catenin and are less well characterized. Dishevelled (Dvl) is a key component of ... [more]
Mol. Cell. Biol. Jun. 01, 2004; 24(11);4757-68 [Pubmed: 15143170]
Throughput
- Low Throughput
Ontology Terms
- phenotype: abnormal protein level (MP:0008469)
Additional Notes
- expression of DKK1 inhibits the activation of beta-catenin induced by expression of Wnt1
Curated By
- BioGRID