BAIT
SFRP2
AI851596, Sdf5
secreted frizzled-related protein 2
GO Process (60)
GO Function (5)
GO Component (1)
Gene Ontology Biological Process
- Wnt signaling pathway involved in somitogenesis [IGI]
- anterior/posterior pattern specification [IGI]
- apoptotic process [IMP]
- bone morphogenesis [IMP]
- cardiac left ventricle morphogenesis [ISO]
- cartilage development [IMP]
- cellular response to X-ray [IDA]
- cellular response to extracellular stimulus [IDA]
- chondrocyte development [IMP]
- collagen fibril organization [IMP]
- convergent extension involved in axis elongation [IGI]
- development of primary male sexual characteristics [IGI]
- digestive tract morphogenesis [IGI]
- embryonic digit morphogenesis [IMP]
- hematopoietic stem cell proliferation [IDA]
- male gonad development [IGI]
- negative regulation of BMP signaling pathway [IDA, IGI]
- negative regulation of JUN kinase activity [IGI]
- negative regulation of Wnt signaling pathway [IDA, ISO]
- negative regulation of canonical Wnt signaling pathway [IDA, IGI, ISO]
- negative regulation of cardiac muscle cell apoptotic process [IDA]
- negative regulation of cell growth [ISO]
- negative regulation of cell migration [IDA]
- negative regulation of cell proliferation [ISO]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- negative regulation of dermatome development [IDA]
- negative regulation of epithelial cell proliferation [ISO]
- negative regulation of epithelial to mesenchymal transition [ISO]
- negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [IDA]
- negative regulation of gene expression [IDA]
- negative regulation of mesodermal cell fate specification [IGI]
- negative regulation of peptidyl-tyrosine phosphorylation [IDA]
- negative regulation of planar cell polarity pathway involved in axis elongation [IGI]
- negative regulation of transcription, DNA-templated [ISO]
- neural tube closure [IGI]
- neural tube development [IGI]
- outflow tract morphogenesis [ISO]
- patterning of blood vessels [IDA]
- planar cell polarity pathway involved in neural tube closure [IGI]
- positive regulation of angiogenesis [IDA]
- positive regulation of apoptotic process [ISO]
- positive regulation of canonical Wnt signaling pathway [IDA, IGI]
- positive regulation of catenin import into nucleus [IDA]
- positive regulation of cell growth [IDA]
- positive regulation of cell proliferation [IDA, ISO]
- positive regulation of endopeptidase activity [IDA]
- positive regulation of fat cell differentiation [ISO]
- positive regulation of osteoblast differentiation [IGI]
- positive regulation of peptidyl-serine phosphorylation [IDA]
- positive regulation of receptor activity [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- post-anal tail morphogenesis [IMP]
- regulation of Wnt signaling pathway [IDA]
- regulation of apoptotic process [IMP]
- regulation of cell proliferation [IMP]
- regulation of establishment of planar polarity [IGI]
- regulation of stem cell division [IDA]
- response to drug [IDA]
- signal transduction [IDA]
- somitogenesis [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
VANGL2
C530001F03Rik, Lp, Lpp1, Ltap, Vang1l2, loop-tail, ska17, ska, stbm, strabismus
vang-like 2 (van gogh, Drosophila)
GO Process (45)
GO Function (1)
GO Component (11)
Gene Ontology Biological Process
- Rho protein signal transduction [IMP]
- Wnt signaling pathway, planar cell polarity pathway [IGI, IMP]
- anterior/posterior pattern specification [IMP]
- apical protein localization [IMP]
- cardiac vascular smooth muscle cell differentiation [TAS]
- cell migration involved in kidney development [IMP]
- cochlea development [IGI]
- cochlea morphogenesis [IGI, IMP]
- convergent extension involved in axis elongation [IMP]
- convergent extension involved in neural plate elongation [IGI, IMP]
- convergent extension involved in organogenesis [IGI]
- digestive tract morphogenesis [IGI]
- epicardial cell to mesenchymal cell transition [TAS]
- establishment of body hair planar orientation [IMP]
- establishment of epithelial cell polarity [TAS]
- establishment of planar polarity [IGI, IMP]
- establishment of planar polarity involved in neural tube closure [IMP]
- establishment or maintenance of epithelial cell apical/basal polarity [IMP]
- glomerulus development [IMP]
- hair follicle development [IMP]
- heart looping [IMP]
- inner ear receptor cell development [IGI]
- inner ear receptor stereocilium organization [IGI, IMP]
- kidney morphogenesis [IMP]
- lateral sprouting involved in lung morphogenesis [IMP]
- membranous septum morphogenesis [IGI]
- muscular septum morphogenesis [IGI]
- neural tube closure [IGI, IMP]
- non-canonical Wnt signaling pathway [IMP]
- nonmotile primary cilium assembly [IGI]
- orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis [IMP]
- outflow tract septum morphogenesis [TAS]
- patterning of blood vessels [TAS]
- planar cell polarity pathway involved in axis elongation [IGI]
- planar cell polarity pathway involved in heart morphogenesis [IMP]
- planar cell polarity pathway involved in neural tube closure [IGI, IMP]
- planar dichotomous subdivision of terminal units involved in lung branching morphogenesis [IMP]
- positive regulation of JUN kinase activity [IGI]
- post-anal tail morphogenesis [IMP]
- regulation of Wnt signaling pathway [IMP]
- regulation of actin cytoskeleton organization [IMP]
- regulation of establishment of planar polarity [IGI]
- somatic stem cell division [IMP]
- somatic stem cell maintenance [IMP]
- wound healing [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Phenotypic Enhancement
A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Sfrp1, Sfrp2, and Sfrp5 regulate the Wnt/beta-catenin and the planar cell polarity pathways during early trunk formation in mouse.
Sfrp is a secreted Wnt antagonist that directly interacts with Wnt ligand. We show here that inactivation of Sfrp1, Sfrp2, and Sfrp5 leads to fused somites formation in early-somite mouse embryos, simultaneously resulting in defective convergent extension (CE), which causes severe shortening of the anteroposterior axis. These observations indicate the redundant roles of Sfrp1, Sfrp2, and Sfrp5 in early trunk ... [more]
Genesis Feb. 01, 2008; 46(2);92-103 [Pubmed: 18257070]
Throughput
- Low Throughput
Ontology Terms
- spina bifida (MP:0003054)
Additional Notes
- genetic complex
- heterozygosity of Spf2 increases incidence of spina bifida in a Vangle2/Sfrp1/Sfrp5 mutant background
Curated By
- BioGRID