BAIT
TRRAP
PAF350/400, PAF400, STAF40, TR-AP, Tra1
transformation/transcription domain-associated protein
GO Process (7)
GO Function (3)
GO Component (8)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
MED16
DRIP92, THRAP5, TRAP95
mediator complex subunit 16
GO Process (8)
GO Function (7)
GO Component (4)
Gene Ontology Biological Process
- androgen receptor signaling pathway [IDA]
- gene expression [TAS]
- intracellular steroid hormone receptor signaling pathway [IDA]
- positive regulation of receptor activity [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of transcription from RNA polymerase II promoter [NAS]
- transcription from RNA polymerase II promoter [TAS]
- transcription initiation from RNA polymerase II promoter [IDA, TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Co-purification
An interaction is inferred from the identification of two or more protein subunits in a purified protein complex, as obtained by classical biochemical fractionation or affinity purification and one or more additional fractionation steps.
Publication
Cooperative activity of cdk8 and GCN5L within Mediator directs tandem phosphoacetylation of histone H3.
The human Mediator complex is generally required for expression of protein-coding genes. Here, we show that the GCN5L acetyltransferase stably associates with Mediator together with the TRRAP polypeptide. Yet, contrary to expectations, TRRAP/GCN5L does not associate with the transcriptionally active core Mediator but rather with Mediator that contains the cdk8 subcomplex. Consequently, this derivative 'T/G-Mediator' complex does not directly activate ... [more]
EMBO J. May. 21, 2008; 27(10);1447-57 [Pubmed: 18418385]
Throughput
- Low Throughput
Curated By
- BioGRID