BAIT
WNT7A
AI849442, Wnt-7a, px, tw
wingless-type MMTV integration site family, member 7A
GO Process (55)
GO Function (5)
GO Component (4)
Gene Ontology Biological Process
- Wnt signaling pathway involved in wound healing, spreading of epidermal cells [ISO]
- angiogenesis [IGI]
- asymmetric protein localization [IDA]
- canonical Wnt signaling pathway [IGI, ISO]
- cartilage condensation [ISO]
- cartilage development [IDA]
- cell fate commitment [IBA]
- cell proliferation in forebrain [ISO]
- cell-cell signaling [TAS]
- central nervous system vasculogenesis [IGI]
- cerebellar granule cell differentiation [IDA]
- chondrocyte differentiation [ISO]
- dorsal/ventral pattern formation [IMP]
- embryonic axis specification [ISO]
- embryonic digit morphogenesis [ISO]
- embryonic forelimb morphogenesis [IGI, IMP, ISO]
- embryonic hindlimb morphogenesis [IGI, ISO]
- embryonic limb morphogenesis [IGI]
- establishment of cell polarity [IDA]
- forelimb morphogenesis [IMP]
- hindlimb morphogenesis [IMP]
- limb development [IDA]
- negative regulation of apoptotic process [IMP]
- negative regulation of neurogenesis [ISO]
- neurotransmitter secretion [IGI]
- non-canonical Wnt signaling pathway [IGI]
- organ morphogenesis [TAS]
- oviduct development [IMP]
- palate development [ISO]
- positive regulation of JNK cascade [IBA, ISO]
- positive regulation of canonical Wnt signaling pathway [IDA]
- positive regulation of cell proliferation [ISO]
- positive regulation of endothelial cell migration [IDA]
- positive regulation of epithelial cell proliferation involved in wound healing [ISO]
- positive regulation of gene expression [IDA]
- positive regulation of receptor activity [ISO]
- positive regulation of synapse assembly [IDA, ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of transcription, DNA-templated [IDA, ISO]
- regulation of axon diameter [IDA]
- regulation of axonogenesis [IDA]
- regulation of cell proliferation [IMP]
- reproductive structure development [IMP]
- response to estrogen [IMP]
- signal transduction [TAS]
- skeletal muscle satellite cell activation [IDA]
- skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration [IDA]
- skeletal system morphogenesis [IMP]
- skin morphogenesis [IMP]
- somatic stem cell division [IDA]
- somatic stem cell maintenance [IMP]
- stem cell development [ISO]
- synapse organization [IGI, IMP]
- uterus development [IMP]
- uterus morphogenesis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
DVL1
Dvl, mKIAA4029, RP23-242K15.15-003
dishevelled, dsh homolog 1 (Drosophila)
GO Process (34)
GO Function (6)
GO Component (14)
Gene Ontology Biological Process
- Wnt signaling pathway [IGI, NAS, TAS]
- Wnt signaling pathway, planar cell polarity pathway [IDA, IGI, IMP, ISO]
- axon extension [IDA]
- axon guidance [IDA]
- axonogenesis [IDA]
- canonical Wnt signaling pathway [IDA, IGI, IMP, ISO]
- cochlea morphogenesis [IGI]
- collateral sprouting [IDA]
- convergent extension involved in neural plate elongation [IGI]
- convergent extension involved in organogenesis [IGI, IMP]
- cytoplasmic microtubule organization [IDA, IGI]
- dendrite morphogenesis [IMP]
- negative regulation of protein binding [ISO]
- negative regulation of protein kinase activity [ISO]
- negative regulation of protein phosphorylation [IGI]
- neuromuscular junction development [IGI]
- neurotransmitter secretion [IGI]
- planar cell polarity pathway involved in neural tube closure [IGI]
- positive regulation of Wnt signaling pathway [ISO]
- positive regulation of canonical Wnt signaling pathway [IMP]
- positive regulation of neuron projection development [IMP]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISO]
- positive regulation of protein phosphorylation [IDA]
- positive regulation of transcription, DNA-templated [ISO]
- prepulse inhibition [IMP]
- protein localization to microtubule [IGI]
- protein localization to nucleus [ISO]
- receptor clustering [IGI]
- regulation of neurotransmitter levels [IMP]
- regulation of protein phosphorylation [IGI]
- skeletal muscle acetylcholine-gated channel clustering [IMP]
- social behavior [IMP]
- synapse organization [IGI, IMP]
- transcription from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Phenotypic Enhancement
A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Signaling across the synapse: a role for Wnt and Dishevelled in presynaptic assembly and neurotransmitter release.
Proper dialogue between presynaptic neurons and their targets is essential for correct synaptic assembly and function. At central synapses, Wnt proteins function as retrograde signals to regulate axon remodeling and the accumulation of presynaptic proteins. Loss of Wnt7a function leads to defects in the localization of presynaptic markers and in the morphology of the presynaptic axons. We show that loss ... [more]
J. Cell Biol. Jul. 03, 2006; 174(1);127-39 [Pubmed: 16818724]
Throughput
- Low Throughput
Ontology Terms
- phenotype: abnormal synapse morphology (MP:0009538)
Curated By
- BioGRID