BAIT

GSK3B

glycogen synthase kinase 3 beta
GO Process (35)
GO Function (11)
GO Component (7)

Gene Ontology Biological Process

Homo sapiens
PREY

DVL1

Dvl, mKIAA4029, RP23-242K15.15-003
dishevelled, dsh homolog 1 (Drosophila)
GO Process (34)
GO Function (6)
GO Component (14)

Gene Ontology Biological Process

Mus musculus

Phenotypic Suppression

A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

Overexpression of the mouse dishevelled-1 protein inhibits GSK-3beta-mediated phosphorylation of tau in transfected mammalian cells.

Wagner U, Brownlees J, Irving NG, Lucas FR, Salinas PC, Miller CC

Tau is a neuronal microtubule-associated protein whose function is modulated by phosphorylation. GSK-3beta is a tau kinase. GSK-3beta is part of the wingless signalling pathway and stimulation by wingless is predicted to down-regulate GSK-3beta activity. In Drosophila imaginal disc cells, overexpression of dishevelled, a component of the wingless pathway, mimics the wingless signal. We have therefore studied the effect that ... [more]

FEBS Lett. Jul. 14, 1997; 411(2);369-72 [Pubmed: 9271238]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: abnormal protein level (MP:0008469)

Additional Notes

  • co-expression of Dvl1 decreases the phosphorylation of tau seen upon overexpression of GSK3-beta

Curated By

  • BioGRID