DVL1
Gene Ontology Biological Process
- Wnt signaling pathway [IGI, NAS, TAS]
- Wnt signaling pathway, planar cell polarity pathway [IDA, IGI, IMP, ISO]
- axon extension [IDA]
- axon guidance [IDA]
- axonogenesis [IDA]
- canonical Wnt signaling pathway [IDA, IGI, IMP, ISO]
- cochlea morphogenesis [IGI]
- collateral sprouting [IDA]
- convergent extension involved in neural plate elongation [IGI]
- convergent extension involved in organogenesis [IGI, IMP]
- cytoplasmic microtubule organization [IDA, IGI]
- dendrite morphogenesis [IMP]
- negative regulation of protein binding [ISO]
- negative regulation of protein kinase activity [ISO]
- negative regulation of protein phosphorylation [IGI]
- neuromuscular junction development [IGI]
- neurotransmitter secretion [IGI]
- planar cell polarity pathway involved in neural tube closure [IGI]
- positive regulation of Wnt signaling pathway [ISO]
- positive regulation of canonical Wnt signaling pathway [IMP]
- positive regulation of neuron projection development [IMP]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISO]
- positive regulation of protein phosphorylation [IDA]
- positive regulation of transcription, DNA-templated [ISO]
- prepulse inhibition [IMP]
- protein localization to microtubule [IGI]
- protein localization to nucleus [ISO]
- receptor clustering [IGI]
- regulation of neurotransmitter levels [IMP]
- regulation of protein phosphorylation [IGI]
- skeletal muscle acetylcholine-gated channel clustering [IMP]
- social behavior [IMP]
- synapse organization [IGI, IMP]
- transcription from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
DVL2
Gene Ontology Biological Process
- Wnt signaling pathway [IDA, ISO, NAS]
- Wnt signaling pathway, planar cell polarity pathway [IGI, ISO]
- canonical Wnt signaling pathway [IDA, IGI, IMP, ISO]
- canonical Wnt signaling pathway involved in regulation of cell proliferation [ISO]
- cellular protein localization [IDA]
- cochlea morphogenesis [IGI]
- convergent extension involved in neural plate elongation [IGI, IMP]
- convergent extension involved in organogenesis [IGI]
- heart development [IMP]
- heart morphogenesis [IGI]
- neural tube closure [IMP]
- non-canonical Wnt signaling pathway [ISO]
- outflow tract morphogenesis [IMP]
- planar cell polarity pathway involved in neural tube closure [IGI, IMP]
- positive regulation of JUN kinase activity [IDA, ISO]
- positive regulation of canonical Wnt signaling pathway [IMP]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of protein tyrosine kinase activity [IGI]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- segment specification [IMP]
- segmentation [IGI]
- transcription from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Phenotypic Enhancement
A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Regulation of polarized extension and planar cell polarity in the cochlea by the vertebrate PCP pathway.
The mammalian auditory sensory organ, the organ of Corti, consists of sensory hair cells with uniformly oriented stereocilia on the apical surfaces and has a distinct planar cell polarity (PCP) parallel to the sensory epithelium. It is not certain how this polarity is achieved during differentiation. Here we show that the organ of Corti is formed from a thicker and ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: abnormal cochlear hair cell stereociliary bundle morphology (MP:0004521)
- phenotype: abnormal cochlea morphology (MP:0000031)
Additional Notes
- double mutant show stereocilia mis-orientation
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| DVL1 DVL2 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 505263 | |
| DVL1 DVL2 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 504991 |
Curated By
- BioGRID