DVL3
Gene Ontology Biological Process
- Wnt signaling pathway [ISO]
- Wnt signaling pathway, planar cell polarity pathway [IGI, ISO, TAS]
- canonical Wnt signaling pathway [ISO, TAS]
- cochlea morphogenesis [IGI]
- heart morphogenesis [IGI]
- non-canonical Wnt signaling pathway [ISO]
- non-canonical Wnt signaling pathway via JNK cascade [IDA]
- outflow tract septum morphogenesis [IMP]
- planar cell polarity pathway involved in neural tube closure [IGI]
- positive regulation of JUN kinase activity [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of transcription, DNA-templated [ISO]
Gene Ontology Molecular Function
VANGL2
Gene Ontology Biological Process
- Rho protein signal transduction [IMP]
- Wnt signaling pathway, planar cell polarity pathway [IGI, IMP]
- anterior/posterior pattern specification [IMP]
- apical protein localization [IMP]
- cardiac vascular smooth muscle cell differentiation [TAS]
- cell migration involved in kidney development [IMP]
- cochlea development [IGI]
- cochlea morphogenesis [IGI, IMP]
- convergent extension involved in axis elongation [IMP]
- convergent extension involved in neural plate elongation [IGI, IMP]
- convergent extension involved in organogenesis [IGI]
- digestive tract morphogenesis [IGI]
- epicardial cell to mesenchymal cell transition [TAS]
- establishment of body hair planar orientation [IMP]
- establishment of epithelial cell polarity [TAS]
- establishment of planar polarity [IGI, IMP]
- establishment of planar polarity involved in neural tube closure [IMP]
- establishment or maintenance of epithelial cell apical/basal polarity [IMP]
- glomerulus development [IMP]
- hair follicle development [IMP]
- heart looping [IMP]
- inner ear receptor cell development [IGI]
- inner ear receptor stereocilium organization [IGI, IMP]
- kidney morphogenesis [IMP]
- lateral sprouting involved in lung morphogenesis [IMP]
- membranous septum morphogenesis [IGI]
- muscular septum morphogenesis [IGI]
- neural tube closure [IGI, IMP]
- non-canonical Wnt signaling pathway [IMP]
- nonmotile primary cilium assembly [IGI]
- orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis [IMP]
- outflow tract septum morphogenesis [TAS]
- patterning of blood vessels [TAS]
- planar cell polarity pathway involved in axis elongation [IGI]
- planar cell polarity pathway involved in heart morphogenesis [IMP]
- planar cell polarity pathway involved in neural tube closure [IGI, IMP]
- planar dichotomous subdivision of terminal units involved in lung branching morphogenesis [IMP]
- positive regulation of JUN kinase activity [IGI]
- post-anal tail morphogenesis [IMP]
- regulation of Wnt signaling pathway [IMP]
- regulation of actin cytoskeleton organization [IMP]
- regulation of establishment of planar polarity [IGI]
- somatic stem cell division [IMP]
- somatic stem cell maintenance [IMP]
- wound healing [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Phenotypic Enhancement
A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Murine dishevelled 3 functions in redundant pathways with dishevelled 1 and 2 in normal cardiac outflow tract, cochlea, and neural tube development.
Dishevelled (Dvl) proteins are important signaling components of both the canonical beta-catenin/Wnt pathway, which controls cell proliferation and patterning, and the planar cell polarity (PCP) pathway, which coordinates cell polarity within a sheet of cells and also directs convergent extension cell (CE) movements that produce narrowing and elongation of the tissue. Three mammalian Dvl genes have been identified and the ... [more]
Throughput
- Low Throughput
Ontology Terms
- abnormal neural tube morphology/development (MP:0002151)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| VANGL2 DVL3 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID