BAIT
DVL1
Dvl, mKIAA4029, RP23-242K15.15-003
dishevelled, dsh homolog 1 (Drosophila)
GO Process (34)
GO Function (6)
GO Component (14)
Gene Ontology Biological Process
- Wnt signaling pathway [IGI, NAS, TAS]
- Wnt signaling pathway, planar cell polarity pathway [IDA, IGI, IMP, ISO]
- axon extension [IDA]
- axon guidance [IDA]
- axonogenesis [IDA]
- canonical Wnt signaling pathway [IDA, IGI, IMP, ISO]
- cochlea morphogenesis [IGI]
- collateral sprouting [IDA]
- convergent extension involved in neural plate elongation [IGI]
- convergent extension involved in organogenesis [IGI, IMP]
- cytoplasmic microtubule organization [IDA, IGI]
- dendrite morphogenesis [IMP]
- negative regulation of protein binding [ISO]
- negative regulation of protein kinase activity [ISO]
- negative regulation of protein phosphorylation [IGI]
- neuromuscular junction development [IGI]
- neurotransmitter secretion [IGI]
- planar cell polarity pathway involved in neural tube closure [IGI]
- positive regulation of Wnt signaling pathway [ISO]
- positive regulation of canonical Wnt signaling pathway [IMP]
- positive regulation of neuron projection development [IMP]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISO]
- positive regulation of protein phosphorylation [IDA]
- positive regulation of transcription, DNA-templated [ISO]
- prepulse inhibition [IMP]
- protein localization to microtubule [IGI]
- protein localization to nucleus [ISO]
- receptor clustering [IGI]
- regulation of neurotransmitter levels [IMP]
- regulation of protein phosphorylation [IGI]
- skeletal muscle acetylcholine-gated channel clustering [IMP]
- social behavior [IMP]
- synapse organization [IGI, IMP]
- transcription from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
DVL3
dishevelled 3, dsh homolog (Drosophila)
GO Process (12)
GO Function (6)
GO Component (2)
Gene Ontology Biological Process
- Wnt signaling pathway [ISO]
- Wnt signaling pathway, planar cell polarity pathway [IGI, ISO, TAS]
- canonical Wnt signaling pathway [ISO, TAS]
- cochlea morphogenesis [IGI]
- heart morphogenesis [IGI]
- non-canonical Wnt signaling pathway [ISO]
- non-canonical Wnt signaling pathway via JNK cascade [IDA]
- outflow tract septum morphogenesis [IMP]
- planar cell polarity pathway involved in neural tube closure [IGI]
- positive regulation of JUN kinase activity [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of transcription, DNA-templated [ISO]
Gene Ontology Molecular Function
Mus musculus
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Murine dishevelled 3 functions in redundant pathways with dishevelled 1 and 2 in normal cardiac outflow tract, cochlea, and neural tube development.
Dishevelled (Dvl) proteins are important signaling components of both the canonical beta-catenin/Wnt pathway, which controls cell proliferation and patterning, and the planar cell polarity (PCP) pathway, which coordinates cell polarity within a sheet of cells and also directs convergent extension cell (CE) movements that produce narrowing and elongation of the tissue. Three mammalian Dvl genes have been identified and the ... [more]
PLoS Genet. Nov. 01, 2008; 4(11);e1000259 [Pubmed: 19008950]
Throughput
- Low Throughput
Ontology Terms
- phenotype: embryonic lethality (MP:0008762)
Curated By
- BioGRID