BAIT
DVL2
RP23-172M21.1
dishevelled 2, dsh homolog (Drosophila)
GO Process (23)
GO Function (5)
GO Component (9)
Gene Ontology Biological Process
- Wnt signaling pathway [IDA, ISO, NAS]
- Wnt signaling pathway, planar cell polarity pathway [IGI, ISO]
- canonical Wnt signaling pathway [IDA, IGI, IMP, ISO]
- canonical Wnt signaling pathway involved in regulation of cell proliferation [ISO]
- cellular protein localization [IDA]
- cochlea morphogenesis [IGI]
- convergent extension involved in neural plate elongation [IGI, IMP]
- convergent extension involved in organogenesis [IGI]
- heart development [IMP]
- heart morphogenesis [IGI]
- neural tube closure [IMP]
- non-canonical Wnt signaling pathway [ISO]
- outflow tract morphogenesis [IMP]
- planar cell polarity pathway involved in neural tube closure [IGI, IMP]
- positive regulation of JUN kinase activity [IDA, ISO]
- positive regulation of canonical Wnt signaling pathway [IMP]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of protein tyrosine kinase activity [IGI]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- segment specification [IMP]
- segmentation [IGI]
- transcription from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
DVL3
dishevelled 3, dsh homolog (Drosophila)
GO Process (12)
GO Function (6)
GO Component (2)
Gene Ontology Biological Process
- Wnt signaling pathway [ISO]
- Wnt signaling pathway, planar cell polarity pathway [IGI, ISO, TAS]
- canonical Wnt signaling pathway [ISO, TAS]
- cochlea morphogenesis [IGI]
- heart morphogenesis [IGI]
- non-canonical Wnt signaling pathway [ISO]
- non-canonical Wnt signaling pathway via JNK cascade [IDA]
- outflow tract septum morphogenesis [IMP]
- planar cell polarity pathway involved in neural tube closure [IGI]
- positive regulation of JUN kinase activity [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of transcription, DNA-templated [ISO]
Gene Ontology Molecular Function
Mus musculus
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Murine dishevelled 3 functions in redundant pathways with dishevelled 1 and 2 in normal cardiac outflow tract, cochlea, and neural tube development.
Dishevelled (Dvl) proteins are important signaling components of both the canonical beta-catenin/Wnt pathway, which controls cell proliferation and patterning, and the planar cell polarity (PCP) pathway, which coordinates cell polarity within a sheet of cells and also directs convergent extension cell (CE) movements that produce narrowing and elongation of the tissue. Three mammalian Dvl genes have been identified and the ... [more]
PLoS Genet. Nov. 01, 2008; 4(11);e1000259 [Pubmed: 19008950]
Throughput
- Low Throughput
Ontology Terms
- phenotype: embryonic lethality (MP:0008762)
Curated By
- BioGRID