BAIT
PARP1
ARTD1, Adprt, Parp-1
poly (ADP-ribose) polymerase 1
GO Process (16)
GO Function (9)
GO Component (8)
Gene Ontology Biological Process
- DNA damage response, detection of DNA damage [IDA]
- DNA metabolic process [ISO]
- base-excision repair [ISO]
- cellular response to insulin stimulus [ISO]
- cellular response to superoxide [ISO]
- double-strand break repair [IBA, ISO, ISS]
- positive regulation of SMAD protein import into nucleus [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of transcription regulatory region DNA binding [IMP]
- protein ADP-ribosylation [IDA, ISO]
- protein autoprocessing [IDA]
- protein poly-ADP-ribosylation [IMP, ISO]
- regulation of growth rate [ISO]
- signal transduction involved in regulation of gene expression [IMP]
- telomere maintenance [ISO]
- transforming growth factor beta receptor signaling pathway [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
RAD50
RAD50 homolog (S. cerevisiae)
GO Process (15)
GO Function (6)
GO Component (11)
Gene Ontology Biological Process
- DNA catabolic process, endonucleolytic [ISO, ISS]
- DNA duplex unwinding [ISO]
- DNA recombination [ISO, ISS]
- DNA repair [ISO, ISS]
- cellular response to DNA damage stimulus [ISO]
- double-strand break repair [ISO, ISS, TAS]
- negative regulation of viral entry into host cell [IMP]
- nucleic acid phosphodiester bond hydrolysis [ISO, ISS]
- positive regulation of kinase activity [ISO]
- positive regulation of protein autophosphorylation [ISO]
- protein heterooligomerization [IDA]
- reciprocal meiotic recombination [TAS]
- regulation of mitotic recombination [ISO, ISS]
- telomere maintenance [TAS]
- telomere maintenance via telomerase [ISO, ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
Activating the PARP-1 sensor component of the groucho/ TLE1 corepressor complex mediates a CaMKinase IIdelta-dependent neurogenic gene activation pathway.
Switching specific patterns of gene repression and activation in response to precise temporal/spatial signals is critical for normal development. Here we report a pathway in which induction of CaMKIIdelta triggers an unexpected switch in the function of the HES1 transcription factor from a TLE-dependent repressor to an activator required for neuronal differentiation. These events are based on activation of the ... [more]
Cell Dec. 17, 2004; 119(6);815-29 [Pubmed: 15607978]
Throughput
- Low Throughput
Additional Notes
- ChIP
Curated By
- BioGRID