BAIT
PARP1
ARTD1, Adprt, Parp-1
poly (ADP-ribose) polymerase 1
GO Process (16)
GO Function (9)
GO Component (8)
Gene Ontology Biological Process
- DNA damage response, detection of DNA damage [IDA]
- DNA metabolic process [ISO]
- base-excision repair [ISO]
- cellular response to insulin stimulus [ISO]
- cellular response to superoxide [ISO]
- double-strand break repair [IBA, ISO, ISS]
- positive regulation of SMAD protein import into nucleus [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of transcription regulatory region DNA binding [IMP]
- protein ADP-ribosylation [IDA, ISO]
- protein autoprocessing [IDA]
- protein poly-ADP-ribosylation [IMP, ISO]
- regulation of growth rate [ISO]
- signal transduction involved in regulation of gene expression [IMP]
- telomere maintenance [ISO]
- transforming growth factor beta receptor signaling pathway [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
NPM1
B23NP
nucleophosmin (nucleolar phosphoprotein B23, numatrin)
GO Process (38)
GO Function (17)
GO Component (16)
Gene Ontology Biological Process
- DNA repair [ISO, ISS]
- cell aging [ISO, ISS]
- cell growth [ISO]
- cell volume homeostasis [ISO]
- centrosome cycle [ISO, ISS]
- negative regulation of apoptotic process [ISO, ISS]
- negative regulation of cell proliferation [ISO, ISS]
- negative regulation of centrosome duplication [ISO]
- negative regulation of mRNA splicing, via spliceosome [ISO]
- negative regulation of protein kinase activity by regulation of protein phosphorylation [ISO, ISS]
- nucleocytoplasmic transport [ISO]
- nucleosome assembly [ISO]
- positive regulation of DNA metabolic process [IDA]
- positive regulation of DNA replication [IDA]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of catalytic activity [IDA]
- positive regulation of cell proliferation [ISO]
- positive regulation of cellular biosynthetic process [ISO]
- positive regulation of centrosome duplication [ISO]
- positive regulation of protein kinase activity [ISO]
- positive regulation of translation [ISO, ISS]
- protein destabilization [ISO]
- protein homooligomerization [IDA]
- protein localization [ISO]
- protein oligomerization [ISO]
- rRNA export from nucleus [ISO]
- regulation of DNA damage response, signal transduction by p53 class mediator [ISO]
- regulation of cell cycle [ISO]
- regulation of centriole replication [ISO, ISS]
- regulation of centrosome duplication [ISO]
- regulation of eIF2 alpha phosphorylation by dsRNA [ISO, ISS]
- regulation of endodeoxyribonuclease activity [ISO, ISS]
- regulation of endoribonuclease activity [ISO, ISS]
- regulation of neuron apoptotic process [IMP]
- ribosomal large subunit biogenesis [ISO]
- ribosomal large subunit export from nucleus [ISO]
- ribosomal small subunit biogenesis [ISO]
- ribosomal small subunit export from nucleus [ISO]
Gene Ontology Molecular Function- DNA binding [IDA]
- NF-kappaB binding [ISO, ISS]
- RNA binding [ISO]
- Tat protein binding [ISO]
- enzyme binding [IDA, IPI]
- histone binding [ISO]
- phosphatidylinositol-3,4,5-trisphosphate binding [IPI]
- poly(A) RNA binding [ISO]
- protein heterodimerization activity [ISO]
- protein homodimerization activity [ISO]
- protein kinase binding [ISO]
- protein kinase inhibitor activity [ISO, ISS]
- rRNA binding [ISO]
- ribosomal large subunit binding [ISO]
- ribosomal small subunit binding [ISO]
- transcription coactivator activity [ISO]
- unfolded protein binding [ISO, ISS]
- DNA binding [IDA]
- NF-kappaB binding [ISO, ISS]
- RNA binding [ISO]
- Tat protein binding [ISO]
- enzyme binding [IDA, IPI]
- histone binding [ISO]
- phosphatidylinositol-3,4,5-trisphosphate binding [IPI]
- poly(A) RNA binding [ISO]
- protein heterodimerization activity [ISO]
- protein homodimerization activity [ISO]
- protein kinase binding [ISO]
- protein kinase inhibitor activity [ISO, ISS]
- rRNA binding [ISO]
- ribosomal large subunit binding [ISO]
- ribosomal small subunit binding [ISO]
- transcription coactivator activity [ISO]
- unfolded protein binding [ISO, ISS]
Gene Ontology Cellular Component
- cell [ISO]
- centrosome [ISO, ISS]
- cytoplasm [ISO, ISS]
- cytosol [ISO]
- focal adhesion [ISO]
- granular component [ISO]
- intracellular [ISO]
- large ribosomal subunit [ISO]
- membrane [ISO]
- nuclear speck [ISO]
- nucleolus [IDA, ISO]
- nucleoplasm [ISO]
- nucleus [ISO, ISS]
- ribonucleoprotein complex [ISO]
- small ribosomal subunit [ISO]
- spindle pole centrosome [ISO]
Rattus norvegicus
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
Activating the PARP-1 sensor component of the groucho/ TLE1 corepressor complex mediates a CaMKinase IIdelta-dependent neurogenic gene activation pathway.
Switching specific patterns of gene repression and activation in response to precise temporal/spatial signals is critical for normal development. Here we report a pathway in which induction of CaMKIIdelta triggers an unexpected switch in the function of the HES1 transcription factor from a TLE-dependent repressor to an activator required for neuronal differentiation. These events are based on activation of the ... [more]
Cell Dec. 17, 2004; 119(6);815-29 [Pubmed: 15607978]
Throughput
- Low Throughput
Additional Notes
- ChIP
Curated By
- BioGRID