BAIT
PARP1
ARTD1, Adprt, Parp-1
poly (ADP-ribose) polymerase 1
GO Process (16)
GO Function (9)
GO Component (8)
Gene Ontology Biological Process
- DNA damage response, detection of DNA damage [IDA]
- DNA metabolic process [ISO]
- base-excision repair [ISO]
- cellular response to insulin stimulus [ISO]
- cellular response to superoxide [ISO]
- double-strand break repair [IBA, ISO, ISS]
- positive regulation of SMAD protein import into nucleus [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of transcription regulatory region DNA binding [IMP]
- protein ADP-ribosylation [IDA, ISO]
- protein autoprocessing [IDA]
- protein poly-ADP-ribosylation [IMP, ISO]
- regulation of growth rate [ISO]
- signal transduction involved in regulation of gene expression [IMP]
- telomere maintenance [ISO]
- transforming growth factor beta receptor signaling pathway [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
HIST1H4B
H1ft, Hist4, Hist4h4
histone cluster 1, H4b
GO Process (3)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
Activating the PARP-1 sensor component of the groucho/ TLE1 corepressor complex mediates a CaMKinase IIdelta-dependent neurogenic gene activation pathway.
Switching specific patterns of gene repression and activation in response to precise temporal/spatial signals is critical for normal development. Here we report a pathway in which induction of CaMKIIdelta triggers an unexpected switch in the function of the HES1 transcription factor from a TLE-dependent repressor to an activator required for neuronal differentiation. These events are based on activation of the ... [more]
Cell Dec. 17, 2004; 119(6);815-29 [Pubmed: 15607978]
Throughput
- Low Throughput
Additional Notes
- ChIP
Curated By
- BioGRID