BAIT
PARP1
ARTD1, Adprt, Parp-1
poly (ADP-ribose) polymerase 1
GO Process (16)
GO Function (9)
GO Component (8)
Gene Ontology Biological Process
- DNA damage response, detection of DNA damage [IDA]
- DNA metabolic process [ISO]
- base-excision repair [ISO]
- cellular response to insulin stimulus [ISO]
- cellular response to superoxide [ISO]
- double-strand break repair [IBA, ISO, ISS]
- positive regulation of SMAD protein import into nucleus [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of transcription regulatory region DNA binding [IMP]
- protein ADP-ribosylation [IDA, ISO]
- protein autoprocessing [IDA]
- protein poly-ADP-ribosylation [IMP, ISO]
- regulation of growth rate [ISO]
- signal transduction involved in regulation of gene expression [IMP]
- telomere maintenance [ISO]
- transforming growth factor beta receptor signaling pathway [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
CAMK2A
PK2CDD, PKCCD
calcium/calmodulin-dependent protein kinase II alpha
GO Process (13)
GO Function (8)
GO Component (8)
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [ISO, ISS]
- calcium ion transport [ISO, ISS]
- ionotropic glutamate receptor signaling pathway [IDA]
- peptidyl-serine phosphorylation [IDA, ISO]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of calcium ion transport [ISO, ISS]
- positive regulation of cardiac muscle cell apoptotic process [ISO, ISS]
- protein autophosphorylation [IDA, IMP, ISO]
- protein phosphorylation [IDA, IMP, ISO]
- regulation of mitochondrial membrane permeability involved in apoptotic process [ISO, ISS]
- regulation of neuronal synaptic plasticity [ISO, ISS]
- regulation of neurotransmitter secretion [ISO, ISS]
- response to ischemia [ISO, ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
Activating the PARP-1 sensor component of the groucho/ TLE1 corepressor complex mediates a CaMKinase IIdelta-dependent neurogenic gene activation pathway.
Switching specific patterns of gene repression and activation in response to precise temporal/spatial signals is critical for normal development. Here we report a pathway in which induction of CaMKIIdelta triggers an unexpected switch in the function of the HES1 transcription factor from a TLE-dependent repressor to an activator required for neuronal differentiation. These events are based on activation of the ... [more]
Cell Dec. 17, 2004; 119(6);815-29 [Pubmed: 15607978]
Throughput
- Low Throughput
Additional Notes
- ChIP
Curated By
- BioGRID