BAIT
HES1
hes family bHLH transcription factor 1
GO Process (75)
GO Function (12)
GO Component (4)
Gene Ontology Biological Process
- Notch signaling pathway [ISO]
- STAT protein import into nucleus [ISO, ISS]
- adenohypophysis development [ISO]
- aorta morphogenesis [ISO]
- artery morphogenesis [ISO]
- ascending aorta morphogenesis [ISO]
- auditory receptor cell differentiation [ISO]
- auditory receptor cell fate determination [ISO]
- cardiac neural crest cell development involved in outflow tract morphogenesis [ISO]
- cell adhesion [ISO]
- cell fate commitment [ISO]
- cell maturation [ISO]
- cell migration [ISO]
- cell morphogenesis involved in neuron differentiation [ISO]
- cochlea development [ISO]
- common bile duct development [ISO]
- embryonic heart tube morphogenesis [ISO]
- forebrain radial glial cell differentiation [IDA]
- hindbrain morphogenesis [ISO]
- in utero embryonic development [ISO]
- labyrinthine layer blood vessel development [ISO]
- lateral inhibition [ISO]
- liver development [ISO]
- lung development [ISO]
- midbrain development [ISO]
- midbrain-hindbrain boundary morphogenesis [ISO]
- negative regulation of auditory receptor cell differentiation [ISO]
- negative regulation of cell differentiation [ISO]
- negative regulation of forebrain neuron differentiation [IDA]
- negative regulation of gene expression [IMP]
- negative regulation of glial cell proliferation [ISO, ISS]
- negative regulation of inner ear receptor cell differentiation [ISO]
- negative regulation of neuron differentiation [ISO]
- negative regulation of oligodendrocyte differentiation [ISO, ISS]
- negative regulation of pancreatic A cell differentiation [ISO]
- negative regulation of pro-B cell differentiation [ISO, ISS]
- negative regulation of stem cell differentiation [ISO]
- negative regulation of stomach neuroendocrine cell differentiation [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IMP, ISO]
- negative regulation of transcription, DNA-templated [IDA, ISO]
- neural tube development [ISO]
- neuronal stem cell maintenance [IDA, ISO]
- oculomotor nerve development [ISO]
- outflow tract morphogenesis [ISO]
- pancreas development [ISO]
- pattern specification process [ISO]
- pharyngeal arch artery morphogenesis [ISO]
- pituitary gland development [ISO]
- positive regulation of BMP signaling pathway [ISO]
- positive regulation of DNA binding [ISO, ISS]
- positive regulation of JAK-STAT cascade [ISO, ISS]
- positive regulation of Notch signaling pathway [ISO]
- positive regulation of T cell proliferation [ISO]
- positive regulation of astrocyte differentiation [ISO, ISS]
- positive regulation of cell proliferation [ISO]
- positive regulation of mitotic cell cycle, embryonic [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- positive regulation of tyrosine phosphorylation of Stat3 protein [ISO, ISS]
- protein complex assembly [ISO, ISS]
- regulation of fat cell differentiation [ISO]
- regulation of neurogenesis [ISO]
- regulation of secondary heart field cardioblast proliferation [ISO]
- regulation of timing of cell differentiation [ISO]
- regulation of timing of neuron differentiation [ISO]
- regulation of transcription from RNA polymerase II promoter [ISO]
- smoothened signaling pathway [ISO]
- somatic stem cell maintenance [ISO]
- telencephalon development [ISO]
- thymus development [ISO]
- transcription from RNA polymerase II promoter [ISO]
- trochlear nerve development [ISO]
- vascular smooth muscle cell development [ISO]
- ventricular septum development [ISO]
- ventricular septum morphogenesis [ISO]
Gene Ontology Molecular Function- DNA binding [ISO]
- E-box binding [IDA]
- N-box binding [ISO, ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [ISO, ISS]
- chaperone binding [ISO]
- histone deacetylase binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO, ISS]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [ISO]
- sequence-specific DNA binding transcription factor activity [ISO]
- transcription factor binding [IPI]
- DNA binding [ISO]
- E-box binding [IDA]
- N-box binding [ISO, ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [ISO, ISS]
- chaperone binding [ISO]
- histone deacetylase binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO, ISS]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [ISO]
- sequence-specific DNA binding transcription factor activity [ISO]
- transcription factor binding [IPI]
Gene Ontology Cellular Component
- cytoplasm [ISO]
- intracellular [ISO]
- nucleoplasm [ISO, TAS]
- nucleus [ISO, ISS]
Rattus norvegicus
PREY
PARP1
ARTD1, Adprt, Parp-1
poly (ADP-ribose) polymerase 1
GO Process (16)
GO Function (9)
GO Component (8)
Gene Ontology Biological Process
- DNA damage response, detection of DNA damage [IDA]
- DNA metabolic process [ISO]
- base-excision repair [ISO]
- cellular response to insulin stimulus [ISO]
- cellular response to superoxide [ISO]
- double-strand break repair [IBA, ISO, ISS]
- positive regulation of SMAD protein import into nucleus [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of transcription regulatory region DNA binding [IMP]
- protein ADP-ribosylation [IDA, ISO]
- protein autoprocessing [IDA]
- protein poly-ADP-ribosylation [IMP, ISO]
- regulation of growth rate [ISO]
- signal transduction involved in regulation of gene expression [IMP]
- telomere maintenance [ISO]
- transforming growth factor beta receptor signaling pathway [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
Activating the PARP-1 sensor component of the groucho/ TLE1 corepressor complex mediates a CaMKinase IIdelta-dependent neurogenic gene activation pathway.
Switching specific patterns of gene repression and activation in response to precise temporal/spatial signals is critical for normal development. Here we report a pathway in which induction of CaMKIIdelta triggers an unexpected switch in the function of the HES1 transcription factor from a TLE-dependent repressor to an activator required for neuronal differentiation. These events are based on activation of the ... [more]
Cell Dec. 17, 2004; 119(6);815-29 [Pubmed: 15607978]
Throughput
- Low Throughput
Additional Notes
- ChIP
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PARP1 HES1 | Co-localization Co-localization Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments. | Low | - | BioGRID | 505277 |
Curated By
- BioGRID