BAIT
MYD88
myeloid differentiation primary response gene 88
GO Process (31)
GO Function (6)
GO Component (6)
Gene Ontology Biological Process
- 3'-UTR-mediated mRNA stabilization [ISO]
- JNK cascade [ISO]
- MyD88-dependent toll-like receptor signaling pathway [IGI, IMP]
- Toll signaling pathway [ISO]
- cell surface receptor signaling pathway [IMP]
- cytokine-mediated signaling pathway [ISO]
- defense response to Gram-positive bacterium [IMP]
- establishment of endothelial intestinal barrier [IMP]
- immune response [TAS]
- immunoglobulin mediated immune response [IMP]
- lipopolysaccharide-mediated signaling pathway [IMP]
- negative regulation of growth of symbiont in host [IMP]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IGI, IMP]
- positive regulation of JNK cascade [IMP]
- positive regulation of NF-kappaB transcription factor activity [IGI, IMP]
- positive regulation of chemokine biosynthetic process [IGI]
- positive regulation of interleukin-17 production [IMP]
- positive regulation of interleukin-23 production [IMP]
- positive regulation of interleukin-6 production [IMP]
- positive regulation of lymphocyte proliferation [IMP]
- positive regulation of smooth muscle cell proliferation [ISO]
- positive regulation of tumor necrosis factor production [IGI, IMP]
- regulation of cell proliferation [IGI]
- regulation of inflammatory response [IMP]
- response to interleukin-1 [ISO]
- response to lipopolysaccharide [IGI, IMP]
- response to molecule of fungal origin [IMP]
- response to peptidoglycan [IMP]
- response to virus [IMP]
- transmembrane receptor protein serine/threonine kinase signaling pathway [TAS]
- type I interferon biosynthetic process [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
CITED2
AI835299, ER154-like, Mrg1, Msg2, p35srj
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
GO Process (69)
GO Function (12)
GO Component (3)
Gene Ontology Biological Process
- adrenal cortex formation [IMP]
- adrenal gland development [IMP]
- blood vessel development [IMP]
- bone morphogenesis [IMP]
- branching involved in ureteric bud morphogenesis [IMP]
- cardiac neural crest cell development involved in heart development [IMP]
- cardiac septum morphogenesis [IMP]
- cell proliferation [ISO]
- central nervous system development [IMP]
- cranial nerve morphogenesis [IMP]
- decidualization [IMP]
- determination of heart left/right asymmetry [IMP]
- determination of left/right symmetry [IMP]
- embryonic camera-type eye morphogenesis [IGI]
- embryonic heart tube left/right pattern formation [IMP]
- embryonic placenta development [IMP]
- embryonic process involved in female pregnancy [IMP]
- endocardial cushion development [IMP]
- erythrocyte development [IMP]
- granulocyte differentiation [IMP]
- heart development [IMP, ISO, ISS]
- heart looping [IMP]
- hematopoietic progenitor cell differentiation [IMP]
- in utero embryonic development [IMP]
- kidney development [IMP]
- left/right axis specification [IMP]
- lens morphogenesis in camera-type eye [IMP]
- leukocyte differentiation [IMP]
- liver development [IMP]
- male gonad development [IGI]
- morphogenesis of an epithelium [IMP]
- negative regulation of apoptotic process [IMP]
- negative regulation of cell migration [ISO]
- negative regulation of gene expression [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- negative regulation of transcription from RNA polymerase II promoter in response to hypoxia [ISO]
- negative regulation of transcription, DNA-templated [ISO, ISS]
- neural tube closure [IMP]
- neural tube formation [IMP]
- nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry [IMP]
- outflow tract morphogenesis [IMP]
- peripheral nervous system development [IMP]
- positive regulation of cell cycle [IMP]
- positive regulation of cell-cell adhesion [IMP]
- positive regulation of gene expression [ISO]
- positive regulation of male gonad development [IMP]
- positive regulation of peroxisome proliferator activated receptor signaling pathway [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP, ISO]
- positive regulation of transcription, DNA-templated [IDA, ISO]
- positive regulation of transforming growth factor beta receptor signaling pathway [IDA]
- pulmonary artery morphogenesis [IMP]
- regulation of nucleic acid-templated transcription [ISO]
- regulation of organ formation [IMP]
- regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of transcription, DNA-templated [TAS]
- response to estrogen [ISO]
- response to fluid shear stress [ISO]
- response to hypoxia [ISO, ISS]
- sex determination [IMP]
- skeletal muscle cell differentiation [IMP]
- spleen development [IMP]
- thymus development [IGI, IMP]
- transcription from RNA polymerase II promoter [ISO]
- transforming growth factor beta receptor signaling pathway [IDA]
- trophectodermal cell differentiation [IMP]
- vasculature development [IGI, IMP]
- vasculogenesis [IMP]
- ventricular septum development [IMP]
- ventricular septum morphogenesis [IMP]
Gene Ontology Molecular Function- LBD domain binding [ISO]
- RNA polymerase II activating transcription factor binding [IPI]
- RNA polymerase II transcription coactivator activity [IDA]
- RNA polymerase II transcription corepressor activity [ISO]
- SMAD binding [IPI]
- chromatin binding [IDA]
- histone acetyltransferase binding [ISO]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription coactivator activity [IDA, ISO, ISS]
- transcription cofactor activity [TAS]
- transcription corepressor activity [ISO]
- LBD domain binding [ISO]
- RNA polymerase II activating transcription factor binding [IPI]
- RNA polymerase II transcription coactivator activity [IDA]
- RNA polymerase II transcription corepressor activity [ISO]
- SMAD binding [IPI]
- chromatin binding [IDA]
- histone acetyltransferase binding [ISO]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription coactivator activity [IDA, ISO, ISS]
- transcription cofactor activity [TAS]
- transcription corepressor activity [ISO]
Mus musculus
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Negative feedback regulation of NF-κB action by CITED2 in the nucleus.
NF-κB is a family of important transcription factors that modulate immunity, development, inflammation, and cancer. The biological activity of NF-κB is subjected to various spatial and temporal regulations. Bioinformatics analysis predicts that CITED2 is topologically close to NF-κB in the protein interaction networks. In this study, we show that ectopic expression or knockdown of CITED2 attenuates or potentiates, respectively, the ... [more]
J. Immunol. Jan. 01, 2011; 186(1);539-48 [Pubmed: 21098220]
Throughput
- Low Throughput
Ontology Terms
- phenotype: abnormal protein level (MP:0008469)
Additional Notes
- transfection of cited2 decreases the activation of an NF-kB reporter normally seen upon overexpression of myd88, traf6, RelA or IKKbeta
Curated By
- BioGRID