BAIT
TRAF6
2310003F17Rik, AI851288, C630032O20Rik, RP23-313G3.1
TNF receptor-associated factor 6
GO Process (44)
GO Function (13)
GO Component (12)
Gene Ontology Biological Process
- I-kappaB kinase/NF-kappaB signaling [IMP]
- JNK cascade [ISO]
- T cell receptor signaling pathway [ISO]
- T-helper 1 type immune response [IMP]
- activation of NF-kappaB-inducing kinase activity [ISO]
- activation of protein kinase activity [ISO]
- antigen processing and presentation of exogenous peptide antigen via MHC class II [IMP]
- bone remodeling [IMP]
- bone resorption [IMP]
- cell development [IMP]
- cellular response to lipopolysaccharide [ISO]
- cytokine-mediated signaling pathway [ISO]
- immune response [IMP]
- interleukin-1-mediated signaling pathway [IMP, ISO]
- myeloid dendritic cell differentiation [IMP]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- negative regulation of transcription, DNA-templated [ISO]
- neural tube closure [IMP]
- odontogenesis of dentin-containing tooth [IMP]
- organ morphogenesis [IMP]
- ossification [IMP]
- osteoclast differentiation [IMP]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IGI, IMP, ISO]
- positive regulation of JUN kinase activity [ISO]
- positive regulation of NF-kappaB transcription factor activity [IMP, ISO]
- positive regulation of T cell cytokine production [ISO]
- positive regulation of T cell proliferation [IMP]
- positive regulation of interleukin-12 biosynthetic process [IMP]
- positive regulation of interleukin-2 production [ISO]
- positive regulation of interleukin-6 biosynthetic process [IMP]
- positive regulation of lipopolysaccharide-mediated signaling pathway [IMP]
- positive regulation of osteoclast differentiation [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- positive regulation of smooth muscle cell proliferation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of transcription regulatory region DNA binding [ISO]
- protein K63-linked ubiquitination [IDA, ISO]
- protein autoubiquitination [ISO, TAS]
- protein complex assembly [ISO]
- protein polyubiquitination [ISO]
- protein ubiquitination [IDA, IGI, IMP]
- regulation of immunoglobulin secretion [IDA]
- response to interleukin-1 [ISO]
- signal transduction [IDA, TAS]
Gene Ontology Molecular Function- histone deacetylase binding [ISO]
- mitogen-activated protein kinase kinase kinase binding [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein kinase B binding [ISO]
- protein kinase binding [ISO]
- signal transducer activity [TAS]
- thioesterase binding [ISO]
- tumor necrosis factor receptor binding [ISO]
- ubiquitin conjugating enzyme binding [ISO]
- ubiquitin protein ligase activity [IDA, IMP]
- ubiquitin protein ligase binding [ISO]
- ubiquitin-protein transferase activity [IDA, ISO]
- histone deacetylase binding [ISO]
- mitogen-activated protein kinase kinase kinase binding [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein kinase B binding [ISO]
- protein kinase binding [ISO]
- signal transducer activity [TAS]
- thioesterase binding [ISO]
- tumor necrosis factor receptor binding [ISO]
- ubiquitin conjugating enzyme binding [ISO]
- ubiquitin protein ligase activity [IDA, IMP]
- ubiquitin protein ligase binding [ISO]
- ubiquitin-protein transferase activity [IDA, ISO]
Gene Ontology Cellular Component
Mus musculus
PREY
CITED2
AI835299, ER154-like, Mrg1, Msg2, p35srj
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
GO Process (69)
GO Function (12)
GO Component (3)
Gene Ontology Biological Process
- adrenal cortex formation [IMP]
- adrenal gland development [IMP]
- blood vessel development [IMP]
- bone morphogenesis [IMP]
- branching involved in ureteric bud morphogenesis [IMP]
- cardiac neural crest cell development involved in heart development [IMP]
- cardiac septum morphogenesis [IMP]
- cell proliferation [ISO]
- central nervous system development [IMP]
- cranial nerve morphogenesis [IMP]
- decidualization [IMP]
- determination of heart left/right asymmetry [IMP]
- determination of left/right symmetry [IMP]
- embryonic camera-type eye morphogenesis [IGI]
- embryonic heart tube left/right pattern formation [IMP]
- embryonic placenta development [IMP]
- embryonic process involved in female pregnancy [IMP]
- endocardial cushion development [IMP]
- erythrocyte development [IMP]
- granulocyte differentiation [IMP]
- heart development [IMP, ISO, ISS]
- heart looping [IMP]
- hematopoietic progenitor cell differentiation [IMP]
- in utero embryonic development [IMP]
- kidney development [IMP]
- left/right axis specification [IMP]
- lens morphogenesis in camera-type eye [IMP]
- leukocyte differentiation [IMP]
- liver development [IMP]
- male gonad development [IGI]
- morphogenesis of an epithelium [IMP]
- negative regulation of apoptotic process [IMP]
- negative regulation of cell migration [ISO]
- negative regulation of gene expression [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- negative regulation of transcription from RNA polymerase II promoter in response to hypoxia [ISO]
- negative regulation of transcription, DNA-templated [ISO, ISS]
- neural tube closure [IMP]
- neural tube formation [IMP]
- nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry [IMP]
- outflow tract morphogenesis [IMP]
- peripheral nervous system development [IMP]
- positive regulation of cell cycle [IMP]
- positive regulation of cell-cell adhesion [IMP]
- positive regulation of gene expression [ISO]
- positive regulation of male gonad development [IMP]
- positive regulation of peroxisome proliferator activated receptor signaling pathway [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP, ISO]
- positive regulation of transcription, DNA-templated [IDA, ISO]
- positive regulation of transforming growth factor beta receptor signaling pathway [IDA]
- pulmonary artery morphogenesis [IMP]
- regulation of nucleic acid-templated transcription [ISO]
- regulation of organ formation [IMP]
- regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of transcription, DNA-templated [TAS]
- response to estrogen [ISO]
- response to fluid shear stress [ISO]
- response to hypoxia [ISO, ISS]
- sex determination [IMP]
- skeletal muscle cell differentiation [IMP]
- spleen development [IMP]
- thymus development [IGI, IMP]
- transcription from RNA polymerase II promoter [ISO]
- transforming growth factor beta receptor signaling pathway [IDA]
- trophectodermal cell differentiation [IMP]
- vasculature development [IGI, IMP]
- vasculogenesis [IMP]
- ventricular septum development [IMP]
- ventricular septum morphogenesis [IMP]
Gene Ontology Molecular Function- LBD domain binding [ISO]
- RNA polymerase II activating transcription factor binding [IPI]
- RNA polymerase II transcription coactivator activity [IDA]
- RNA polymerase II transcription corepressor activity [ISO]
- SMAD binding [IPI]
- chromatin binding [IDA]
- histone acetyltransferase binding [ISO]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription coactivator activity [IDA, ISO, ISS]
- transcription cofactor activity [TAS]
- transcription corepressor activity [ISO]
- LBD domain binding [ISO]
- RNA polymerase II activating transcription factor binding [IPI]
- RNA polymerase II transcription coactivator activity [IDA]
- RNA polymerase II transcription corepressor activity [ISO]
- SMAD binding [IPI]
- chromatin binding [IDA]
- histone acetyltransferase binding [ISO]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription coactivator activity [IDA, ISO, ISS]
- transcription cofactor activity [TAS]
- transcription corepressor activity [ISO]
Mus musculus
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Negative feedback regulation of NF-κB action by CITED2 in the nucleus.
NF-κB is a family of important transcription factors that modulate immunity, development, inflammation, and cancer. The biological activity of NF-κB is subjected to various spatial and temporal regulations. Bioinformatics analysis predicts that CITED2 is topologically close to NF-κB in the protein interaction networks. In this study, we show that ectopic expression or knockdown of CITED2 attenuates or potentiates, respectively, the ... [more]
J. Immunol. Jan. 01, 2011; 186(1);539-48 [Pubmed: 21098220]
Throughput
- Low Throughput
Ontology Terms
- abnormal protein level (MP:0008469)
Additional Notes
- transfection of cited2 decreases the activation of an NF-kB reporter normally seen upon overexpression of myd88, traf6, RelA or IKKbeta
Curated By
- BioGRID