BAIT
RELA
p65
v-rel reticuloendotheliosis viral oncogene homolog A (avian)
GO Process (41)
GO Function (25)
GO Component (8)
Gene Ontology Biological Process
- NIK/NF-kappaB signaling [IBA]
- cellular response to hydrogen peroxide [ISO]
- cellular response to interleukin-1 [ISO]
- cellular response to interleukin-6 [ISO]
- cellular response to nicotine [ISO]
- cellular response to peptide hormone stimulus [ISO]
- cellular response to stress [IBA]
- cellular response to tumor necrosis factor [ISO]
- cytokine-mediated signaling pathway [ISO]
- defense response [IMP]
- hair follicle development [IMP]
- inflammatory response [ISO]
- innate immune response [IBA]
- liver development [IMP]
- negative regulation of apoptotic process [IDA, ISO]
- negative regulation of extrinsic apoptotic signaling pathway [IDA, ISO]
- negative regulation of insulin receptor signaling pathway [ISO]
- negative regulation of protein catabolic process [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IBA, ISO]
- negative regulation of transcription, DNA-templated [ISO]
- nucleotide-binding oligomerization domain containing 2 signaling pathway [ISO]
- organ morphogenesis [IMP]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- positive regulation of NF-kappaB transcription factor activity [IDA, ISO]
- positive regulation of Schwann cell differentiation [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of chondrocyte differentiation [ISO]
- positive regulation of interleukin-12 biosynthetic process [IDA]
- positive regulation of miRNA metabolic process [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IBA, ISO]
- positive regulation of transcription, DNA-templated [IDA, IMP, ISO, TAS]
- regulation of inflammatory response [IDA]
- regulation of transcription from RNA polymerase II promoter [IDA]
- response to UV-B [ISO]
- response to bacterium [IDA]
- response to cytokine [IBA]
- response to interleukin-1 [ISO]
- response to muramyl dipeptide [IDA]
- response to muscle stretch [IDA]
- response to organic substance [ISO]
- transcription from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function- DNA binding [IDA, ISO]
- NF-kappaB binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA, ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- activating transcription factor binding [ISO]
- ankyrin repeat binding [IPI]
- chromatin binding [IDA, ISO]
- enzyme binding [IPI]
- identical protein binding [ISO]
- phosphate ion binding [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase binding [IPI, ISO]
- repressing transcription factor binding [ISO]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO]
- ubiquitin protein ligase binding [ISO]
- DNA binding [IDA, ISO]
- NF-kappaB binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA, ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- activating transcription factor binding [ISO]
- ankyrin repeat binding [IPI]
- chromatin binding [IDA, ISO]
- enzyme binding [IPI]
- identical protein binding [ISO]
- phosphate ion binding [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase binding [IPI, ISO]
- repressing transcription factor binding [ISO]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
Mus musculus
PREY
CITED2
AI835299, ER154-like, Mrg1, Msg2, p35srj
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
GO Process (69)
GO Function (12)
GO Component (3)
Gene Ontology Biological Process
- adrenal cortex formation [IMP]
- adrenal gland development [IMP]
- blood vessel development [IMP]
- bone morphogenesis [IMP]
- branching involved in ureteric bud morphogenesis [IMP]
- cardiac neural crest cell development involved in heart development [IMP]
- cardiac septum morphogenesis [IMP]
- cell proliferation [ISO]
- central nervous system development [IMP]
- cranial nerve morphogenesis [IMP]
- decidualization [IMP]
- determination of heart left/right asymmetry [IMP]
- determination of left/right symmetry [IMP]
- embryonic camera-type eye morphogenesis [IGI]
- embryonic heart tube left/right pattern formation [IMP]
- embryonic placenta development [IMP]
- embryonic process involved in female pregnancy [IMP]
- endocardial cushion development [IMP]
- erythrocyte development [IMP]
- granulocyte differentiation [IMP]
- heart development [IMP, ISO, ISS]
- heart looping [IMP]
- hematopoietic progenitor cell differentiation [IMP]
- in utero embryonic development [IMP]
- kidney development [IMP]
- left/right axis specification [IMP]
- lens morphogenesis in camera-type eye [IMP]
- leukocyte differentiation [IMP]
- liver development [IMP]
- male gonad development [IGI]
- morphogenesis of an epithelium [IMP]
- negative regulation of apoptotic process [IMP]
- negative regulation of cell migration [ISO]
- negative regulation of gene expression [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- negative regulation of transcription from RNA polymerase II promoter in response to hypoxia [ISO]
- negative regulation of transcription, DNA-templated [ISO, ISS]
- neural tube closure [IMP]
- neural tube formation [IMP]
- nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry [IMP]
- outflow tract morphogenesis [IMP]
- peripheral nervous system development [IMP]
- positive regulation of cell cycle [IMP]
- positive regulation of cell-cell adhesion [IMP]
- positive regulation of gene expression [ISO]
- positive regulation of male gonad development [IMP]
- positive regulation of peroxisome proliferator activated receptor signaling pathway [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP, ISO]
- positive regulation of transcription, DNA-templated [IDA, ISO]
- positive regulation of transforming growth factor beta receptor signaling pathway [IDA]
- pulmonary artery morphogenesis [IMP]
- regulation of nucleic acid-templated transcription [ISO]
- regulation of organ formation [IMP]
- regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of transcription, DNA-templated [TAS]
- response to estrogen [ISO]
- response to fluid shear stress [ISO]
- response to hypoxia [ISO, ISS]
- sex determination [IMP]
- skeletal muscle cell differentiation [IMP]
- spleen development [IMP]
- thymus development [IGI, IMP]
- transcription from RNA polymerase II promoter [ISO]
- transforming growth factor beta receptor signaling pathway [IDA]
- trophectodermal cell differentiation [IMP]
- vasculature development [IGI, IMP]
- vasculogenesis [IMP]
- ventricular septum development [IMP]
- ventricular septum morphogenesis [IMP]
Gene Ontology Molecular Function- LBD domain binding [ISO]
- RNA polymerase II activating transcription factor binding [IPI]
- RNA polymerase II transcription coactivator activity [IDA]
- RNA polymerase II transcription corepressor activity [ISO]
- SMAD binding [IPI]
- chromatin binding [IDA]
- histone acetyltransferase binding [ISO]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription coactivator activity [IDA, ISO, ISS]
- transcription cofactor activity [TAS]
- transcription corepressor activity [ISO]
- LBD domain binding [ISO]
- RNA polymerase II activating transcription factor binding [IPI]
- RNA polymerase II transcription coactivator activity [IDA]
- RNA polymerase II transcription corepressor activity [ISO]
- SMAD binding [IPI]
- chromatin binding [IDA]
- histone acetyltransferase binding [ISO]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription coactivator activity [IDA, ISO, ISS]
- transcription cofactor activity [TAS]
- transcription corepressor activity [ISO]
Mus musculus
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Negative feedback regulation of NF-κB action by CITED2 in the nucleus.
NF-κB is a family of important transcription factors that modulate immunity, development, inflammation, and cancer. The biological activity of NF-κB is subjected to various spatial and temporal regulations. Bioinformatics analysis predicts that CITED2 is topologically close to NF-κB in the protein interaction networks. In this study, we show that ectopic expression or knockdown of CITED2 attenuates or potentiates, respectively, the ... [more]
J. Immunol. Jan. 01, 2011; 186(1);539-48 [Pubmed: 21098220]
Throughput
- Low Throughput
Ontology Terms
- abnormal protein level (MP:0008469)
Additional Notes
- transfection of cited2 decreases the activation of an NF-kB reporter normally seen upon overexpression of myd88, traf6, RelA or IKKbeta
Curated By
- BioGRID