CITED2
Gene Ontology Biological Process
- adrenal cortex formation [IMP]
- adrenal gland development [IMP]
- blood vessel development [IMP]
- bone morphogenesis [IMP]
- branching involved in ureteric bud morphogenesis [IMP]
- cardiac neural crest cell development involved in heart development [IMP]
- cardiac septum morphogenesis [IMP]
- cell proliferation [ISO]
- central nervous system development [IMP]
- cranial nerve morphogenesis [IMP]
- decidualization [IMP]
- determination of heart left/right asymmetry [IMP]
- determination of left/right symmetry [IMP]
- embryonic camera-type eye morphogenesis [IGI]
- embryonic heart tube left/right pattern formation [IMP]
- embryonic placenta development [IMP]
- embryonic process involved in female pregnancy [IMP]
- endocardial cushion development [IMP]
- erythrocyte development [IMP]
- granulocyte differentiation [IMP]
- heart development [IMP, ISO, ISS]
- heart looping [IMP]
- hematopoietic progenitor cell differentiation [IMP]
- in utero embryonic development [IMP]
- kidney development [IMP]
- left/right axis specification [IMP]
- lens morphogenesis in camera-type eye [IMP]
- leukocyte differentiation [IMP]
- liver development [IMP]
- male gonad development [IGI]
- morphogenesis of an epithelium [IMP]
- negative regulation of apoptotic process [IMP]
- negative regulation of cell migration [ISO]
- negative regulation of gene expression [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- negative regulation of transcription from RNA polymerase II promoter in response to hypoxia [ISO]
- negative regulation of transcription, DNA-templated [ISO, ISS]
- neural tube closure [IMP]
- neural tube formation [IMP]
- nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry [IMP]
- outflow tract morphogenesis [IMP]
- peripheral nervous system development [IMP]
- positive regulation of cell cycle [IMP]
- positive regulation of cell-cell adhesion [IMP]
- positive regulation of gene expression [ISO]
- positive regulation of male gonad development [IMP]
- positive regulation of peroxisome proliferator activated receptor signaling pathway [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP, ISO]
- positive regulation of transcription, DNA-templated [IDA, ISO]
- positive regulation of transforming growth factor beta receptor signaling pathway [IDA]
- pulmonary artery morphogenesis [IMP]
- regulation of nucleic acid-templated transcription [ISO]
- regulation of organ formation [IMP]
- regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of transcription, DNA-templated [TAS]
- response to estrogen [ISO]
- response to fluid shear stress [ISO]
- response to hypoxia [ISO, ISS]
- sex determination [IMP]
- skeletal muscle cell differentiation [IMP]
- spleen development [IMP]
- thymus development [IGI, IMP]
- transcription from RNA polymerase II promoter [ISO]
- transforming growth factor beta receptor signaling pathway [IDA]
- trophectodermal cell differentiation [IMP]
- vasculature development [IGI, IMP]
- vasculogenesis [IMP]
- ventricular septum development [IMP]
- ventricular septum morphogenesis [IMP]
Gene Ontology Molecular Function- LBD domain binding [ISO]
- RNA polymerase II activating transcription factor binding [IPI]
- RNA polymerase II transcription coactivator activity [IDA]
- RNA polymerase II transcription corepressor activity [ISO]
- SMAD binding [IPI]
- chromatin binding [IDA]
- histone acetyltransferase binding [ISO]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription coactivator activity [IDA, ISO, ISS]
- transcription cofactor activity [TAS]
- transcription corepressor activity [ISO]
- LBD domain binding [ISO]
- RNA polymerase II activating transcription factor binding [IPI]
- RNA polymerase II transcription coactivator activity [IDA]
- RNA polymerase II transcription corepressor activity [ISO]
- SMAD binding [IPI]
- chromatin binding [IDA]
- histone acetyltransferase binding [ISO]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription coactivator activity [IDA, ISO, ISS]
- transcription cofactor activity [TAS]
- transcription corepressor activity [ISO]
CREBBP
Gene Ontology Biological Process
- N-terminal peptidyl-lysine acetylation [ISO]
- cell proliferation [ISO]
- germ-line stem cell maintenance [IMP]
- histone acetylation [IDA, ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of G1/S transition of mitotic cell cycle [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [TAS]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, ISO]
- positive regulation of transcription, DNA-templated [IDA, ISO]
- regulation of transcription, DNA-templated [IDA, ISO]
- transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function- DNA binding [IDA]
- MRF binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- RNA polymerase II transcription factor binding [ISO]
- RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription [ISO]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- SMAD binding [ISO]
- acetyltransferase activity [IDA, ISO]
- activating transcription factor binding [ISO]
- chromatin binding [IDA]
- core promoter proximal region sequence-specific DNA binding [ISO]
- histone acetyltransferase activity [IDA, ISO]
- p53 binding [ISO]
- peroxisome proliferator activated receptor binding [ISO]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [ISO]
- transcription coactivator activity [ISO, TAS]
- transcription factor binding [IPI, ISO]
- DNA binding [IDA]
- MRF binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- RNA polymerase II transcription factor binding [ISO]
- RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription [ISO]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- SMAD binding [ISO]
- acetyltransferase activity [IDA, ISO]
- activating transcription factor binding [ISO]
- chromatin binding [IDA]
- core promoter proximal region sequence-specific DNA binding [ISO]
- histone acetyltransferase activity [IDA, ISO]
- p53 binding [ISO]
- peroxisome proliferator activated receptor binding [ISO]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [ISO]
- transcription coactivator activity [ISO, TAS]
- transcription factor binding [IPI, ISO]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Negative feedback regulation of NF-κB action by CITED2 in the nucleus.
NF-κB is a family of important transcription factors that modulate immunity, development, inflammation, and cancer. The biological activity of NF-κB is subjected to various spatial and temporal regulations. Bioinformatics analysis predicts that CITED2 is topologically close to NF-κB in the protein interaction networks. In this study, we show that ectopic expression or knockdown of CITED2 attenuates or potentiates, respectively, the ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CREBBP CITED2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| CREBBP CITED2 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID