BAIT
TNF
DIF, TNF-alpha, TNFA, TNFSF2, DADB-70P7.1
tumor necrosis factor
GO Process (75)
GO Function (6)
GO Component (9)
Gene Ontology Biological Process
- MAPK cascade [IMP]
- activation of MAPK activity [IDA]
- activation of MAPKKK activity [IDA]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- apoptotic process [TAS]
- apoptotic signaling pathway [TAS]
- cellular response to nicotine [IDA]
- cellular response to organic cyclic compound [IDA]
- chronic inflammatory response to antigenic stimulus [IMP]
- embryonic digestive tract development [IEP]
- extrinsic apoptotic signaling pathway [IDA]
- extrinsic apoptotic signaling pathway via death domain receptors [IDA, NAS]
- inflammatory response [IDA]
- leukocyte tethering or rolling [IDA]
- lipopolysaccharide-mediated signaling pathway [IDA]
- necroptotic signaling pathway [IDA]
- negative regulation of branching involved in lung morphogenesis [IDA]
- negative regulation of cytokine secretion involved in immune response [IDA]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [IDA]
- negative regulation of fat cell differentiation [NAS]
- negative regulation of gene expression [IDA]
- negative regulation of interleukin-6 production [IDA]
- negative regulation of lipid catabolic process [IDA]
- negative regulation of lipid storage [NAS]
- negative regulation of protein complex disassembly [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- negative regulation of viral genome replication [IDA]
- positive regulation of ERK1 and ERK2 cascade [NAS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- positive regulation of JUN kinase activity [IDA]
- positive regulation of MAP kinase activity [IDA]
- positive regulation of NF-kappaB import into nucleus [IDA]
- positive regulation of NF-kappaB transcription factor activity [IDA]
- positive regulation of NFAT protein import into nucleus [IDA]
- positive regulation of apoptotic process [IDA]
- positive regulation of calcidiol 1-monooxygenase activity [IDA]
- positive regulation of chemokine (C-X-C motif) ligand 2 production [IDA]
- positive regulation of chemokine biosynthetic process [IDA]
- positive regulation of chemokine production [IDA]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- positive regulation of cytokine production [IDA]
- positive regulation of cytokine secretion [IDA]
- positive regulation of fever generation [ISS]
- positive regulation of gene expression [IDA]
- positive regulation of heterotypic cell-cell adhesion [IDA]
- positive regulation of interleukin-8 biosynthetic process [IDA]
- positive regulation of membrane protein ectodomain proteolysis [IDA]
- positive regulation of mononuclear cell migration [NAS]
- positive regulation of nitric oxide biosynthetic process [IDA]
- positive regulation of osteoclast differentiation [IDA]
- positive regulation of peptidyl-serine phosphorylation [IDA]
- positive regulation of podosome assembly [IDA]
- positive regulation of programmed cell death [IDA]
- positive regulation of protein complex assembly [IDA]
- positive regulation of protein complex disassembly [IDA]
- positive regulation of protein localization to cell surface [IDA]
- positive regulation of protein phosphorylation [IDA]
- positive regulation of protein transport [IDA]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- positive regulation of smooth muscle cell proliferation [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI]
- positive regulation of transcription, DNA-templated [IDA]
- positive regulation of vitamin D biosynthetic process [IDA]
- protein import into nucleus, translocation [IDA]
- protein kinase B signaling [IMP]
- receptor biosynthetic process [IDA]
- regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- regulation of insulin secretion [IDA]
- response to glucocorticoid [IDA]
- response to salt stress [TAS]
- response to virus [IDA]
- sequestering of triglyceride [IDA]
- transformed cell apoptotic process [IDA]
- tumor necrosis factor-mediated signaling pathway [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CDC42
CDC42Hs, G25K, RP1-224A6.5
cell division cycle 42
GO Process (25)
GO Function (7)
GO Component (14)
Gene Ontology Biological Process
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- GTP catabolic process [TAS]
- Golgi organization [ISS]
- T cell costimulation [TAS]
- actin cytoskeleton organization [IDA]
- axon guidance [TAS]
- blood coagulation [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- establishment of Golgi localization [ISS]
- establishment or maintenance of cell polarity [TAS]
- innate immune response [TAS]
- macrophage differentiation [TAS]
- muscle cell differentiation [TAS]
- negative regulation of epidermal growth factor receptor signaling pathway [TAS]
- negative regulation of protein complex assembly [IPI]
- organelle transport along microtubule [ISS]
- positive regulation of cytokinesis [IMP]
- positive regulation of muscle cell differentiation [TAS]
- positive regulation of pseudopodium assembly [IDA]
- positive regulation of substrate adhesion-dependent cell spreading [IDA]
- regulation of attachment of spindle microtubules to kinetochore [IMP]
- regulation of filopodium assembly [IDA]
- regulation of small GTPase mediated signal transduction [TAS]
- small GTPase mediated signal transduction [TAS]
- substantia nigra development [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi membrane [ISS]
- cytoplasm [IDA]
- cytoplasmic ribonucleoprotein granule [IDA]
- cytosol [TAS]
- extracellular vesicular exosome [IDA]
- filopodium [IDA]
- focal adhesion [IDA]
- membrane [IDA]
- midbody [IDA]
- mitotic spindle [IDA]
- neuron projection [IDA]
- neuronal cell body [IDA]
- plasma membrane [IDA, TAS]
- spindle midzone [IDA]
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
NAK is recruited to the TNFR1 complex in a TNFalpha-dependent manner and mediates the production of RANTES: identification of endogenous TNFR-interacting proteins by a proteomic approach.
Tumor necrosis factor alpha (TNFalpha) is a proinflammatory cytokine with pleiotropic immunological and biological activities. TNFalpha signaling is triggered by the engagement of soluble TNFalpha to two types of cell surface receptors, TNFR1 and TNFR2. This recruits cytosolic proteins to the intracellular domains of the receptors and initiates signaling to downstream effectors. In this study, we used a proteomic approach ... [more]
J. Biol. Chem. Dec. 17, 2004; 279(51);53266-71 [Pubmed: 15485837]
Throughput
- Low Throughput
Curated By
- BioGRID