BAIT
PCBP1
WBP17, [a]CP-1, alphaCP-1
poly(rC) binding protein 1
GO Process (2)
GO Function (5)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
IL6
Il-6
interleukin 6
GO Process (67)
GO Function (5)
GO Component (5)
Gene Ontology Biological Process
- T cell activation [IGI]
- T-helper 17 cell lineage commitment [IMP]
- branching involved in salivary gland morphogenesis [IDA, IMP]
- cell growth [ISO]
- cell redox homeostasis [ISO]
- cellular response to hydrogen peroxide [ISO]
- cellular response to lipopolysaccharide [IDA, ISO]
- cytokine-mediated signaling pathway [ISO]
- defense response to protozoan [IMP]
- defense response to virus [ISO]
- endocrine pancreas development [IMP]
- epithelial cell proliferation involved in salivary gland morphogenesis [IDA]
- glucagon secretion [IMP]
- glucose homeostasis [IGI]
- hepatic immune response [ISO]
- inflammatory response [ISO]
- interleukin-6-mediated signaling pathway [IDA, ISO]
- muscle cell cellular homeostasis [IGI]
- myeloid cell homeostasis [IMP]
- negative regulation of apoptotic process [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of chemokine biosynthetic process [IDA, IMP]
- negative regulation of collagen biosynthetic process [ISO]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- negative regulation of cytokine secretion [ISO]
- negative regulation of gluconeogenesis [ISO]
- negative regulation of hormone secretion [IDA]
- negative regulation of muscle organ development [ISO]
- negative regulation of neuron death [ISO]
- negative regulation of protein kinase activity [ISO]
- neuron projection development [ISO]
- neutrophil apoptotic process [IDA, IMP, ISO]
- positive regulation of B cell activation [ISO]
- positive regulation of DNA replication [ISO]
- positive regulation of ERK1 and ERK2 cascade [ISO]
- positive regulation of JAK-STAT cascade [ISO]
- positive regulation of MAPK cascade [ISO]
- positive regulation of T cell proliferation [ISO]
- positive regulation of T-helper 2 cell differentiation [IDA]
- positive regulation of acute inflammatory response [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of chemokine production [ISO]
- positive regulation of epithelial cell proliferation [IDA, IMP]
- positive regulation of gene expression [ISO]
- positive regulation of immunoglobulin secretion [ISO]
- positive regulation of interleukin-6 production [ISO]
- positive regulation of neuron differentiation [ISO]
- positive regulation of nitric oxide biosynthetic process [ISO]
- positive regulation of peptidyl-serine phosphorylation [ISO]
- positive regulation of peptidyl-tyrosine phosphorylation [ISO]
- positive regulation of protein import into nucleus, translocation [ISO]
- positive regulation of protein kinase B signaling [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- positive regulation of smooth muscle cell proliferation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IGI, ISO]
- positive regulation of transcription, DNA-templated [IDA, ISO]
- positive regulation of translation [ISO]
- positive regulation of transmission of nerve impulse [ISO]
- positive regulation of tyrosine phosphorylation of Stat3 protein [ISO]
- regulation of apoptotic process [IMP]
- regulation of cell proliferation [IGI]
- regulation of cell shape [ISO]
- regulation of circadian sleep/wake cycle, non-REM sleep [ISO]
- regulation of vascular endothelial growth factor production [ISO]
- response to glucocorticoid [ISO]
- response to wounding [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Protein-RNA
An interaction is detected between and protein and an RNA in vitro.
Publication
An RNA-binding protein alphaCP-1 is involved in the STAT3-mediated suppression of NF-kappaB transcriptional activity.
Signal transducer and activator of transcription 3 (STAT3) has been shown to mediate the anti-inflammatory effect of IL-10. Activated STAT3 suppresses LPS-induced IL-6, tumor necrosis factor-alpha and IL-12 gene expression in macrophages and dendritic cells. However, the mechanism of Toll-like receptor (TLR) signal suppression by STAT3 has not been clarified. In this study, we investigated the effect of constitutively activated ... [more]
Int. Immunol. May. 01, 2007; 19(5);609-19 [Pubmed: 17383969]
Throughput
- Low Throughput
Curated By
- BioGRID