SQSTM1
Gene Ontology Biological Process
- autophagy [ISO]
- positive regulation of macroautophagy [IBA, ISO]
- positive regulation of protein phosphorylation [ISO]
- protein heterooligomerization [ISO]
- regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- regulation of nucleic acid-templated transcription [TAS]
- ubiquitin-dependent protein catabolic process [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PRKCD
Gene Ontology Biological Process
- B cell proliferation [IMP]
- apoptotic process [ISO]
- aspartate transport [ISO]
- cellular senescence [ISO]
- collagen metabolic process [ISO]
- defense response to bacterium [IMP]
- immunoglobulin mediated immune response [IMP]
- interleukin-10 production [IMP]
- interleukin-12 production [IMP]
- intracellular signal transduction [ISO]
- negative regulation of MAP kinase activity [ISO]
- negative regulation of actin filament polymerization [IMP]
- negative regulation of filopodium assembly [IMP]
- negative regulation of glial cell apoptotic process [ISO]
- negative regulation of insulin receptor signaling pathway [IMP]
- negative regulation of peptidyl-tyrosine phosphorylation [IMP]
- negative regulation of platelet aggregation [IMP]
- neutrophil activation [ISO]
- peptidyl-threonine phosphorylation [ISO]
- positive regulation of MAP kinase activity [ISO]
- positive regulation of MAPK cascade [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of apoptotic signaling pathway [IDA]
- positive regulation of ceramide biosynthetic process [ISO]
- positive regulation of glucose import [ISO]
- positive regulation of glucosylceramide catabolic process [ISO]
- positive regulation of phospholipid scramblase activity [ISO]
- positive regulation of protein dephosphorylation [ISO]
- positive regulation of response to DNA damage stimulus [ISO]
- positive regulation of sphingomyelin catabolic process [ISO]
- positive regulation of superoxide anion generation [ISO]
- protein autophosphorylation [ISO]
- protein phosphorylation [IDA, ISO]
- response to oxidative stress [ISO]
- termination of signal transduction [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Sequestosome-1/p62 is the key intracellular target of innate defense regulator peptide.
Innate defense regulator-1 (IDR-1) is a synthetic peptide with no antimicrobial activity that enhances microbial infection control while suppressing inflammation. Previously, the effects of IDR-1 were postulated to impact several regulatory pathways including mitogen-activated protein kinase (MAPK) p38 and CCAAT-enhancer-binding protein, but how this was mediated was unknown. Using a combined stable isotope labeling by amino acids in cell culture-proteomics ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID