PARP1
Gene Ontology Biological Process
- DNA repair [TAS]
- cellular response to insulin stimulus [IDA]
- double-strand break repair [IMP]
- gene expression [TAS]
- macrophage differentiation [TAS]
- negative regulation of transcription from RNA polymerase II promoter [TAS]
- protein ADP-ribosylation [IDA]
- protein poly-ADP-ribosylation [IDA]
- transcription from RNA polymerase II promoter [TAS]
- transcription initiation from RNA polymerase II promoter [TAS]
- transcription, DNA-templated [TAS]
- transforming growth factor beta receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CARM1
Gene Ontology Biological Process
- cellular lipid metabolic process [TAS]
- histone H3-R17 methylation [ISS]
- histone H3-R2 methylation [IMP]
- histone methylation [IDA, ISS]
- peptidyl-arginine methylation, to asymmetrical-dimethyl arginine [IBA]
- positive regulation of fat cell differentiation [ISS]
- regulation of intracellular estrogen receptor signaling pathway [ISS]
- regulation of transcription, DNA-templated [IBA, ISS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function- beta-catenin binding [TAS]
- histone methyltransferase activity [IDA]
- histone methyltransferase activity (H3-R17 specific) [ISS]
- histone-arginine N-methyltransferase activity [IBA]
- ligand-dependent nuclear receptor transcription coactivator activity [ISS]
- lysine-acetylated histone binding [ISS]
- protein binding [IPI]
- protein methyltransferase activity [ISS]
- protein-arginine N-methyltransferase activity [ISS]
- protein-arginine omega-N asymmetric methyltransferase activity [IBA, ISS]
- transcription coactivator activity [ISS]
- transcription regulatory region DNA binding [ISS]
- beta-catenin binding [TAS]
- histone methyltransferase activity [IDA]
- histone methyltransferase activity (H3-R17 specific) [ISS]
- histone-arginine N-methyltransferase activity [IBA]
- ligand-dependent nuclear receptor transcription coactivator activity [ISS]
- lysine-acetylated histone binding [ISS]
- protein binding [IPI]
- protein methyltransferase activity [ISS]
- protein-arginine N-methyltransferase activity [ISS]
- protein-arginine omega-N asymmetric methyltransferase activity [IBA, ISS]
- transcription coactivator activity [ISS]
- transcription regulatory region DNA binding [ISS]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Protein arginine methyltransferase 1 coactivates NF-kappaB-dependent gene expression synergistically with CARM1 and PARP1.
Nuclear factor kappa B (NF-kappaB) plays an important role in the transcriptional regulation of genes involved in inflammation and cell survival. Transcriptional coactivators that methylate histones become increasingly important. Recently, we provided evidence that coactivator-associated arginine methyltransferase 1 (CARM1) is a transcriptional coactivator of NF-kappaB and functions as a promoter-specific regulator of NF-kappaB recruitment to chromatin. Here, we show that ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID