BAIT

HOS2

RTL1, histone deacetylase HOS2, L000004092, L000003448, YGL194C
Histone deacetylase and subunit of Set3 and Rpd3L complexes; required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails; subunit of the Set3 complex, a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; co-localizes with Cmr1p in nuclear foci in response to DNA damage by MMS
Saccharomyces cerevisiae (S288c)
PREY

MSL1

YIB9, YIB9w, L000004502, YIR009W
U2B component of U2 snRNP; involved in splicing, binds the U2 snRNA stem-loop IV in vitro but requires association of Lea1p for in vivo binding; does not contain the conserved C-terminal RNA binding domain found in other family members
GO Process (1)
GO Function (1)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)

Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

Dynamic histone acetylation is critical for cotranscriptional spliceosome assembly and spliceosomal rearrangements.

Gunderson FQ, Merkhofer EC, Johnson TL

Assembly of the spliceosome onto pre-mRNA is a dynamic process involving the ordered exchange of snRNPs to form the catalytically active spliceosome. These ordered rearrangements have recently been shown to occur cotranscriptionally, while the RNA polymerase is still actively engaged with the chromatin template. We previously demonstrated that the histone acetyltransferase Gcn5 is required for U2 snRNP association with the ... [more]

Proc. Natl. Acad. Sci. U.S.A. Feb. 01, 2011; 108(5);2004-9 [Pubmed: 21245291]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: inviable (APO:0000112)

Additional Notes

  • deletion of msl1 increases the temperature sensitivity of a hos2/hos3 mutant
  • genetic complex

Curated By

  • BioGRID