BAIT

PSD1

phosphatidylserine decarboxylase 1, L000001518, YNL169C

Phosphatidylserine decarboxylase of the mitochondrial inner membrane; converts phosphatidylserine to phosphatidylethanolamine; regulates mitochondrial fusion and morphology by affecting lipid mixing in the mitochondrial membrane and by influencing the ratio of long to short forms of Mgm1p; partly exposed to the mitochondrial intermembrane space

GO Process (3)

GO Function (1)

GO Component (2)

Gene Ontology Biological Process

phosphatidylcholine biosynthetic process [IDA]

positive regulation of mitochondrial fusion [IMP]

positive regulation of protein processing [IMP]

Gene Ontology Molecular Function

phosphatidylserine decarboxylase activity [IMP]

Gene Ontology Cellular Component

integral component of mitochondrial inner membrane [IDA]

mitochondrion [IDA]

SGD Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Saccharomyces cerevisiae (S288c)

PREY

PSD2

phosphatidylserine decarboxylase 2, L000002817, YGR170W

Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes; converts phosphatidylserine to phosphatidylethanolamine; controls vacuolar membrane phospholipid content by regulating phospholipids in compartments that will eventually give rise to the vacuole; loss of Psd2p causes a specific reduction in vacuolar membrane PE levels while total PE levels are not significantly affected

GO Process (1)

GO Function (1)

GO Component (1)

Gene Ontology Biological Process

phosphatidylcholine biosynthetic process [IDA]

Gene Ontology Molecular Function

phosphatidylserine decarboxylase activity [IGI]

Gene Ontology Cellular Component

endosome [IDA]

SGD Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Saccharomyces cerevisiae (S288c)

Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

FMP30 is required for the maintenance of a normal cardiolipin level and mitochondrial morphology in the absence of mitochondrial phosphatidylethanolamine synthesis.

Kuroda T, Tani M, Moriguchi A, Tokunaga S, Higuchi T, Kitada S, Kuge O

Mitochondria of the yeast Saccharomyces cerevisiae contain enzymes Crd1p and Psd1p, which synthesize cardiolipin (CL) and phosphatidylethanolamine, respectively. A previous study indicated that crd1Î” is synthetically lethal with psd1Î”. In this study, to identify novel genes involved in CL metabolism, we searched for genes that genetically interact with Psd1p, and found that deletion of FMP30 encoding a mitochondrial inner membrane ... [more]

Unknown Feb. 09, 2011; 0(0); [Pubmed: 21306442]

Throughput

High Throughput

Ontology Terms

phenotype: inviable (APO:0000112)

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
PSD1 PSD2	Dosage Rescue Dosage Rescue A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene.	Mizuike A (2019)	Low	-	BioGRID	2544744
PSD1 PSD2	Dosage Rescue Dosage Rescue A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene.	Wong AKO (2021)	Low	-	BioGRID	3322416
PSD1 PSD2	Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.	Costanzo M (2010)	High	-0.8048	BioGRID	409720
PSD1 PSD2	Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.	Costanzo M (2016)	High	-0.8108	BioGRID	2170810
PSD1 PSD2	Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.	Hoppins S (2011)	High	-13.3854	BioGRID	582618
PSD2 PSD1	Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.	Surma MA (2013)	High	-28.9267	BioGRID	896160
PSD1 PSD2	Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.	Wang Y (2020)	High	-	BioGRID	3026135
PSD1 PSD2	Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.	Wong AKO (2021)	High	-	BioGRID	3322467
PSD1 PSD2	Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.	Lahiri S (2014)	Low	-	BioGRID	1032250
PSD1 PSD2	Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.	Miyata N (2015)	Low	-	BioGRID	1429662
PSD2 PSD1	Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.	Nguyen T (2012)	Low	-	BioGRID	643548
PSD1 PSD2	Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.	Rosenberger S (2009)	Low	-	BioGRID	351929
PSD1 PSD2	Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.	Schuiki I (2010)	Low	-	BioGRID	353804
PSD1 PSD2	Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.	Ye C (2017)	Low	-	BioGRID	2454625
PSD1 PSD2	Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.	Ma M (2018)	Low	-	BioGRID	2460060
PSD1 PSD2	Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.	Horvath SE (2011)	Low	-	BioGRID	559271
PSD1 PSD2	Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.	Iadarola DM (2021)	Low	-	BioGRID	3015450
PSD2 PSD1	Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.	Toh-e A (2002)	Low	-	BioGRID	657481
PSD1 PSD2	Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.	Wang Y (2020)	Low	-	BioGRID	3026132
PSD1 PSD2	Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.	Wong AKO (2021)	Low	-	BioGRID	3322409
PSD1 PSD2	Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.	Ogunbona OB (2017)	Low	-	BioGRID	2346569
PSD1 PSD2	Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.	Storey MK (2001)	Low	-	BioGRID	162613
PSD1 PSD2	Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.	Trotter PJ (1995)	Low	-	BioGRID	483387

Curated By

BioGRID

Interaction Summary

PSD1

Gene Ontology Biological Process

Gene Ontology Molecular Function

phosphatidylserine decarboxylase activity [IMP]

Gene Ontology Cellular Component

PSD2

Gene Ontology Biological Process

Gene Ontology Molecular Function

phosphatidylserine decarboxylase activity [IGI]

Gene Ontology Cellular Component

Synthetic Lethality

Publication

FMP30 is required for the maintenance of a normal cardiolipin level and mitochondrial morphology in the absence of mitochondrial phosphatidylethanolamine synthesis.

Throughput

Ontology Terms

Related interactions

Curated By