CDK5R1
Gene Ontology Biological Process
- G-protein coupled acetylcholine receptor signaling pathway [ISO]
- axon guidance [IMP]
- axonal fasciculation [IMP]
- brain development [IMP]
- cerebellum development [IGI, IMP]
- cerebral cortex radially oriented cell migration [IMP]
- ephrin receptor signaling pathway [IMP]
- hippocampus development [IGI]
- ionotropic glutamate receptor signaling pathway [ISO]
- layer formation in cerebral cortex [IGI]
- negative regulation of axon extension [IGI]
- negative regulation of transcription, DNA-templated [ISO]
- neuron cell-cell adhesion [IMP]
- neuron differentiation [ISO]
- neuron migration [IDA, IGI]
- neuron projection development [ISO]
- peptidyl-serine phosphorylation [ISO]
- peptidyl-threonine phosphorylation [ISO]
- positive regulation of cell cycle arrest [IMP]
- positive regulation of neuron apoptotic process [ISO]
- positive regulation of protein kinase activity [IGI]
- positive regulation of protein serine/threonine kinase activity [IMP, ISO]
- positive regulation of protein targeting to membrane [IDA]
- protein phosphorylation [ISO]
- regulation of actin cytoskeleton organization [IMP]
- regulation of cell cycle [ISO]
- regulation of dendritic spine morphogenesis [IMP]
- regulation of microtubule cytoskeleton organization [IMP]
- serine phosphorylation of STAT3 protein [IDA]
- superior olivary nucleus maturation [IGI]
Gene Ontology Molecular Function- cadherin binding [ISO]
- calcium ion binding [ISO]
- cyclin-dependent protein kinase 5 activator activity [IMP, ISO, TAS]
- cyclin-dependent protein serine/threonine kinase activity [ISO]
- cytoskeletal protein binding [TAS]
- ephrin receptor binding [ISO]
- kinase activity [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- protein serine/threonine kinase activator activity [ISO]
- cadherin binding [ISO]
- calcium ion binding [ISO]
- cyclin-dependent protein kinase 5 activator activity [IMP, ISO, TAS]
- cyclin-dependent protein serine/threonine kinase activity [ISO]
- cytoskeletal protein binding [TAS]
- ephrin receptor binding [ISO]
- kinase activity [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- protein serine/threonine kinase activator activity [ISO]
Gene Ontology Cellular Component
- axon [ISO]
- contractile fiber [ISO]
- cyclin-dependent protein kinase 5 holoenzyme complex [ISO]
- cytoplasm [IDA, ISO]
- dendrite [ISO]
- dendritic spine [ISO]
- growth cone [ISO]
- intracellular membrane-bounded organelle [ISO]
- membrane [ISO]
- neuromuscular junction [ISO]
- neuronal cell body [ISO]
- nucleoplasm [ISO]
- nucleus [IDA, ISO]
- perinuclear region of cytoplasm [ISO]
- postsynaptic density [ISO]
SUDS3
Gene Ontology Biological Process
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Cdk5/p35 phosphorylates mSds3 and regulates mSds3-mediated repression of transcription.
Cyclin-dependent kinase 5 (Cdk5), a serine/threonine kinase that displays kinase activity predominantly in neurons, is activated by two non-cyclin activators, p35 or p39. Here, we report a physical and functional interaction between the Cdk5/p35 complex and mouse Sds3 (mSds3), an essential component of mSin3-histone deacetylase (HDAC) co-repressor complex. mSds3 binds to p35 both in vitro and in vivo, enabling active ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID