RXRA
Gene Ontology Biological Process
- angiogenesis involved in coronary vascular morphogenesis [TAS]
- camera-type eye development [IGI]
- cardiac muscle cell differentiation [TAS]
- cardiac muscle cell proliferation [IGI, IMP, TAS]
- embryo implantation [IGI]
- heart development [IMP, TAS]
- heart morphogenesis [TAS]
- in utero embryonic development [IGI]
- maternal placenta development [IGI]
- mesenchyme development [TAS]
- modulation by virus of host morphology or physiology [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of gene expression [TAS]
- negative regulation of transcription from RNA polymerase II promoter [IGI, ISO]
- peroxisome proliferator activated receptor signaling pathway [ISO]
- placenta development [IMP]
- positive regulation of apoptotic process [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP, ISO]
- positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus [IDA]
- positive regulation of transcription, DNA-templated [IGI, TAS]
- positive regulation of translational initiation by iron [IGI]
- protein homotetramerization [ISO]
- regulation of branching involved in prostate gland morphogenesis [IMP]
- regulation of myelination [ISO]
- regulation of transcription from RNA polymerase II promoter [IGI]
- regulation of transcription, DNA-templated [IDA, ISO]
- response to glucocorticoid [ISO]
- response to retinoic acid [ISO]
- retinoic acid receptor signaling pathway [IDA, IMP, ISO]
- secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development [IMP]
- transcription from RNA polymerase II promoter [IDA]
- ventricular cardiac muscle cell differentiation [IGI, IMP]
- ventricular cardiac muscle tissue morphogenesis [IMP]
- visceral serous pericardium development [TAS]
Gene Ontology Molecular Function- 9-cis retinoic acid receptor activity [IDA]
- DNA binding [IDA, IPI, ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [ISO]
- chromatin DNA binding [IDA]
- double-stranded DNA binding [ISO]
- enzyme binding [ISO]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA, ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein domain specific binding [ISO]
- protein heterodimerization activity [IPI, ISO]
- retinoic acid receptor binding [ISO]
- retinoic acid-responsive element binding [ISO]
- sequence-specific DNA binding [IGI, ISO]
- sequence-specific DNA binding transcription factor activity [IGI, ISO]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA, ISO]
- vitamin D receptor binding [ISO]
- vitamin D response element binding [ISO]
- 9-cis retinoic acid receptor activity [IDA]
- DNA binding [IDA, IPI, ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [ISO]
- chromatin DNA binding [IDA]
- double-stranded DNA binding [ISO]
- enzyme binding [ISO]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA, ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein domain specific binding [ISO]
- protein heterodimerization activity [IPI, ISO]
- retinoic acid receptor binding [ISO]
- retinoic acid-responsive element binding [ISO]
- sequence-specific DNA binding [IGI, ISO]
- sequence-specific DNA binding transcription factor activity [IGI, ISO]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA, ISO]
- vitamin D receptor binding [ISO]
- vitamin D response element binding [ISO]
Gene Ontology Cellular Component
SFPQ
Gene Ontology Biological Process
- RNA splicing [TAS]
- alternative mRNA splicing, via spliceosome [IMP]
- histone H3 deacetylation [ISS]
- mRNA processing [TAS]
- negative regulation of circadian rhythm [ISS]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP]
- negative regulation of transcription, DNA-templated [ISS]
- positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [IDA]
- regulation of circadian rhythm [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
PSF is a novel corepressor that mediates its effect through Sin3A and the DNA binding domain of nuclear hormone receptors.
Members of the type II nuclear hormone receptor subfamily (e.g., thyroid hormone receptors [TRs], retinoic acid receptors, retinoid X receptors [RXRs], vitamin D receptor, and the peroxisome proliferator-activated receptors) bind to their response sequences with or without ligand. In the absence of ligand, these DNA-bound receptors mediate different degrees of repression or silencing of gene expression which is thought to ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID