SIN3A
Gene Ontology Biological Process
- DNA replication [IMP]
- activation of innate immune response [ISO]
- aging [ISO]
- cellular protein localization [IMP]
- cellular response to glucose stimulus [IDA]
- hematopoietic progenitor cell differentiation [IMP]
- histone deacetylation [IBA]
- in utero embryonic development [IMP]
- negative regulation of apoptotic process [IMP]
- negative regulation of circadian rhythm [IMP]
- negative regulation of histone H3-K27 acetylation [ISO]
- negative regulation of protein localization to nucleus [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IGI, ISO]
- negative regulation of transcription regulatory region DNA binding [ISO]
- negative regulation of transcription, DNA-templated [IDA]
- positive regulation of G2/M transition of mitotic cell cycle [IMP]
- positive regulation of chromatin silencing [ISO]
- positive regulation of defense response to virus by host [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- protein deacetylation [ISO]
- regulation of hormone levels [ISO]
- regulation of transcription from RNA polymerase II promoter in response to oxidative stress [ISO]
- regulation of transcription, DNA-templated [IMP]
- response to methylglyoxal [IDA]
- response to organonitrogen compound [ISO]
- transcription from RNA polymerase II promoter [IGI]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA binding [ISO]
- RNA polymerase II activating transcription factor binding [ISO]
- RNA polymerase II repressing transcription factor binding [IPI]
- RNA polymerase II transcription corepressor activity [IGI]
- chromatin binding [IDA]
- histone deacetylase activity [IBA]
- protein binding [IPI]
- protein complex binding [ISO]
- protein deacetylase activity [ISO]
- sequence-specific DNA binding transcription factor activity [IMP]
- transcription corepressor activity [IDA]
- transcription factor binding [IPI]
- transcription regulatory region sequence-specific DNA binding [IDA]
- DNA binding [IDA]
- RNA binding [ISO]
- RNA polymerase II activating transcription factor binding [ISO]
- RNA polymerase II repressing transcription factor binding [IPI]
- RNA polymerase II transcription corepressor activity [IGI]
- chromatin binding [IDA]
- histone deacetylase activity [IBA]
- protein binding [IPI]
- protein complex binding [ISO]
- protein deacetylase activity [ISO]
- sequence-specific DNA binding transcription factor activity [IMP]
- transcription corepressor activity [IDA]
- transcription factor binding [IPI]
- transcription regulatory region sequence-specific DNA binding [IDA]
Gene Ontology Cellular Component
SFPQ
Gene Ontology Biological Process
- RNA splicing [TAS]
- alternative mRNA splicing, via spliceosome [IMP]
- histone H3 deacetylation [ISS]
- mRNA processing [TAS]
- negative regulation of circadian rhythm [ISS]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP]
- negative regulation of transcription, DNA-templated [ISS]
- positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [IDA]
- regulation of circadian rhythm [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
PSF is a novel corepressor that mediates its effect through Sin3A and the DNA binding domain of nuclear hormone receptors.
Members of the type II nuclear hormone receptor subfamily (e.g., thyroid hormone receptors [TRs], retinoic acid receptors, retinoid X receptors [RXRs], vitamin D receptor, and the peroxisome proliferator-activated receptors) bind to their response sequences with or without ligand. In the absence of ligand, these DNA-bound receptors mediate different degrees of repression or silencing of gene expression which is thought to ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SIN3A SFPQ | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID