THRA
Gene Ontology Biological Process
- Type I pneumocyte differentiation [IGI]
- cartilage condensation [IMP]
- cytoplasmic sequestering of transcription factor [IDA]
- erythrocyte differentiation [IMP]
- female courtship behavior [IMP]
- hormone-mediated signaling pathway [ISO]
- intracellular receptor signaling pathway [IDA]
- learning or memory [IMP]
- negative regulation of DNA-templated transcription, initiation [ISO]
- negative regulation of RNA polymerase II transcriptional preinitiation complex assembly [ISO]
- negative regulation of sequence-specific DNA binding transcription factor activity [ISO]
- negative regulation of transcription, DNA-templated [IDA, ISO]
- organ morphogenesis [IMP]
- ossification [IMP]
- positive regulation of female receptivity [IMP]
- positive regulation of myotube differentiation [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- regulation of heart contraction [IMP]
- regulation of lipid catabolic process [IMP]
- regulation of myeloid cell apoptotic process [IMP]
- regulation of thyroid hormone mediated signaling pathway [IMP]
- regulation of transcription from RNA polymerase II promoter [ISO, TAS]
- response to cold [IMP]
- thyroid gland development [IGI]
- transcription from RNA polymerase II promoter [IDA, ISO]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [ISO]
- TBP-class protein binding [ISO]
- chromatin DNA binding [IDA]
- intronic transcription regulatory region DNA binding [ISO]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- protein binding [IPI]
- protein complex binding [IDA]
- protein dimerization activity [ISO]
- protein domain specific binding [ISO]
- protein heterodimerization activity [ISO]
- protein homodimerization activity [ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [ISO]
- single-stranded RNA binding [IDA, ISO]
- steroid receptor RNA activator RNA binding [IDA]
- thyroid hormone binding [ISO]
- thyroid hormone receptor activity [ISO, TAS]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO]
- DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [ISO]
- TBP-class protein binding [ISO]
- chromatin DNA binding [IDA]
- intronic transcription regulatory region DNA binding [ISO]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- protein binding [IPI]
- protein complex binding [IDA]
- protein dimerization activity [ISO]
- protein domain specific binding [ISO]
- protein heterodimerization activity [ISO]
- protein homodimerization activity [ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [ISO]
- single-stranded RNA binding [IDA, ISO]
- steroid receptor RNA activator RNA binding [IDA]
- thyroid hormone binding [ISO]
- thyroid hormone receptor activity [ISO, TAS]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO]
SFPQ
Gene Ontology Biological Process
- RNA splicing [TAS]
- alternative mRNA splicing, via spliceosome [IMP]
- histone H3 deacetylation [ISS]
- mRNA processing [TAS]
- negative regulation of circadian rhythm [ISS]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP]
- negative regulation of transcription, DNA-templated [ISS]
- positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [IDA]
- regulation of circadian rhythm [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
PSF is a novel corepressor that mediates its effect through Sin3A and the DNA binding domain of nuclear hormone receptors.
Members of the type II nuclear hormone receptor subfamily (e.g., thyroid hormone receptors [TRs], retinoic acid receptors, retinoid X receptors [RXRs], vitamin D receptor, and the peroxisome proliferator-activated receptors) bind to their response sequences with or without ligand. In the absence of ligand, these DNA-bound receptors mediate different degrees of repression or silencing of gene expression which is thought to ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID