An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.

Publication

Ligand-dependent activation of the farnesoid X-receptor directs arginine methylation of histone H3 by CARM1.

Ananthanarayanan M, Li S, Balasubramaniyan N, Suchy FJ, Walsh MJ

In this study we demonstrate that the class II nuclear hormone receptor, farnesoid X-receptor (FXR), incorporates histone methyltransferase activity within the gene locus for bile salt export pump (BSEP), a well established FXR target gene that functions as an ATP-dependent canalicular bile acid transporter. This methyltransferase activity is directed specifically to arginine 17 of histone H3. We demonstrate that FXR ... [more]

J. Biol. Chem. Dec. 24, 2004; 279(52);54348-57 [Pubmed: 15471871]

Throughput

Low Throughput

Curated By

BioGRID

Interaction Summary

GRIP1

Gene Ontology Biological Process

Gene Ontology Molecular Function

androgen receptor binding [NAS]beta-catenin binding [TAS]glucocorticoid receptor binding [IPI]protein C-terminus binding [IPI]protein binding [IPI]receptor signaling complex scaffold activity [NAS]transcription coactivator activity [NAS]

Gene Ontology Cellular Component

HIST1H3A