CLR3
Gene Ontology Biological Process
- chromatin silencing at centromere [IMP]
- chromatin silencing at rDNA [IMP]
- chromatin silencing at silent mating-type cassette [IMP]
- chromatin silencing at telomere [IMP]
- histone H3 deacetylation [IMP]
- histone deacetylation [IDA, IMP]
- maintenance of chromatin silencing at silent mating-type cassette [NAS]
- negative regulation of transcription from RNA polymerase II promoter [IGI, IMP]
- nucleosome positioning [IMP]
- regulation of histone methylation [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CLR6
Gene Ontology Biological Process
- chromatin remodeling [NAS]
- chromatin silencing at centromere [IMP]
- chromatin silencing at silent mating-type cassette [IGI]
- histone H3 deacetylation [NAS]
- histone deacetylation [IMP]
- mitotic sister chromatid segregation [TAS]
- negative regulation of transcription from RNA polymerase II promoter [IGI]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of histone H3-K9 methylation [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Phenotypic Enhancement
A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
H3K9me-independent gene silencing in fission yeast heterochromatin by Clr5 and histone deacetylases.
Nucleosomes in heterochromatic regions bear histone modifications that distinguish them from euchromatic nucleosomes. Among those, histone H3 lysine 9 methylation (H3K9me) and hypoacetylation have been evolutionarily conserved and are found in both multicellular eukaryotes and single-cell model organisms such as fission yeast. In spite of numerous studies, the relative contributions of the various heterochromatic histone marks to the properties of ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: mating type switching (APO:0000196)
Additional Notes
- deletion of both genes leads to full derepression of mat2-P
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CLR6 CLR3 | Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell. | Low | - | BioGRID | 435662 | |
| CLR6 CLR3 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 247873 |
Curated By
- BioGRID