RCO1
Gene Ontology Biological Process
Gene Ontology Cellular Component
RSC1
Gene Ontology Biological Process
- ATP-dependent chromatin remodeling [IC, ISS]
- double-strand break repair [IMP]
- double-strand break repair via nonhomologous end joining [IPI]
- nucleosome disassembly [IDA]
- regulation of sporulation resulting in formation of a cellular spore [IMP]
- transcription elongation from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Features of cryptic promoters and their varied reliance on bromodomain-containing factors.
The Set2-Rpd3S pathway is important for the control of transcription memory. Mutation of components of this pathway results in cryptic transcription initiation within the coding region of approximately 30% of yeast genes. Specifically, deletion of the Set2 histone methyltransferase or Rco1, a component of the Rpd3S histone deacetylase complex leads to hyperacetylation of certain open reading frames (ORFs). We used ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: rna accumulation (APO:0000224)
Additional Notes
- deletion of rsc1 partially suppresses the expression of an ste11 cryptic transcript seen upon expression of a degron containing RCO1
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| RCO1 RSC1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -3.6465 | BioGRID | 543053 | |
| RSC1 RCO1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -13.66 | BioGRID | 2359323 |
Curated By
- BioGRID