EXO70
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SRO7
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Dosage Rescue
A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene.
Publication
Yeast Homologs of Lethal Giant Larvae and Type V Myosin Cooperate in the Regulation of Rab-Dependant Vesicle Clustering and Polarized Exocytosis.
Lgl family members play an important role in the regulation of cell polarity in eukaryotic cells. The yeast homologues, Sro7 and Sro77, are thought to act downstream of the Rab GTPase Sec4, to promote SNARE function in post-Golgi transport. In this paper, we characterize the interaction between Sro7 and the type V myosin, Myo2, and show that this interaction is ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: temperature sensitive growth (APO:0000092)
- phenotype: vegetative growth (APO:0000106)
Additional Notes
- expression of SRO7, but not overexpression of SRO7, rescues growth defects
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
EXO70 SRO7 | Dosage Rescue Dosage Rescue A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene. | Low | - | BioGRID | 429371 | |
EXO70 SRO7 | Dosage Rescue Dosage Rescue A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene. | Low | - | BioGRID | 164444 | |
EXO70 SRO7 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.3114 | BioGRID | 1992735 | |
SRO7 EXO70 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID