BAIT
PRKCD
Pkcd
protein kinase C, delta
GO Process (48)
GO Function (9)
GO Component (10)
Gene Ontology Biological Process
- B cell proliferation [ISO]
- aging [IEP]
- apoptotic process [ISO]
- aspartate transport [IMP]
- cellular response to glucose starvation [IEP]
- cellular response to insulin stimulus [IEP]
- cellular senescence [ISO]
- collagen metabolic process [IMP]
- defense response to bacterium [ISO, ISS]
- immunoglobulin mediated immune response [ISO]
- interleukin-10 production [ISO]
- interleukin-12 production [ISO]
- intracellular signal transduction [IDA]
- negative regulation of MAP kinase activity [ISO]
- negative regulation of actin filament polymerization [ISO, ISS]
- negative regulation of filopodium assembly [ISO, ISS]
- negative regulation of glial cell apoptotic process [ISO, ISS]
- negative regulation of insulin receptor signaling pathway [ISO]
- negative regulation of peptidyl-tyrosine phosphorylation [ISO]
- negative regulation of platelet aggregation [ISO, ISS]
- neutrophil activation [ISO]
- peptidyl-threonine phosphorylation [ISO]
- positive regulation of MAP kinase activity [IMP]
- positive regulation of MAPK cascade [IMP]
- positive regulation of apoptotic process [IMP]
- positive regulation of apoptotic signaling pathway [ISO]
- positive regulation of ceramide biosynthetic process [ISO]
- positive regulation of glucose import [IMP]
- positive regulation of glucosylceramide catabolic process [ISO]
- positive regulation of phospholipid scramblase activity [ISO]
- positive regulation of protein dephosphorylation [ISO]
- positive regulation of response to DNA damage stimulus [ISO]
- positive regulation of sphingomyelin catabolic process [ISO]
- positive regulation of superoxide anion generation [ISO, ISS]
- protein autophosphorylation [IDA]
- protein phosphorylation [IDA, ISO]
- response to amino acid [IEP]
- response to drug [IEP]
- response to ethanol [IEP]
- response to glucose [IEP]
- response to heat [IEP]
- response to hydrogen peroxide [IEP]
- response to hypoxia [IEP]
- response to mechanical stimulus [IEP]
- response to organic cyclic compound [IEP]
- response to organonitrogen compound [IEP]
- response to oxidative stress [IMP]
- termination of signal transduction [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
HMGB1
Ac2-008, Hmg1
high mobility group box 1
GO Process (47)
GO Function (22)
GO Component (7)
Gene Ontology Biological Process
- DNA geometric change [IDA]
- V(D)J recombination [ISO]
- actin cytoskeleton reorganization [IMP]
- base-excision repair, DNA ligation [ISO]
- cell morphogenesis [IMP]
- cellular response to interleukin-1 [IEP]
- chemotaxis [IDA]
- chromatin remodeling [IBA]
- circadian rhythm [IEP]
- eye development [ISO]
- induction of positive chemotaxis [IDA]
- inflammatory response to antigenic stimulus [ISO]
- lung development [ISO]
- male-specific defense response to bacterium [IDA]
- myoblast proliferation [IMP]
- negative regulation of DNA replication [IDA]
- negative regulation of RNA polymerase II transcriptional preinitiation complex assembly [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- nervous system development [IMP]
- neuron projection development [IGI]
- positive regulation of DNA binding [ISO]
- positive regulation of apoptotic process [IMP, ISO]
- positive regulation of cell death [IMP]
- positive regulation of cell migration [IDA]
- positive regulation of cell proliferation [IDA]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- positive regulation of glycogen catabolic process [ISO]
- positive regulation of mesenchymal cell proliferation [IDA]
- positive regulation of mitotic cell cycle [IDA]
- positive regulation of myeloid cell apoptotic process [IDA]
- positive regulation of myeloid cell differentiation [ISO]
- positive regulation of myoblast differentiation [IMP]
- positive regulation of neuron projection development [IMP]
- positive regulation of protein kinase activity [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of smooth muscle cell migration [IMP]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- regulation of inflammatory response [IDA]
- regulation of transcription from RNA polymerase II promoter [ISO]
- regulation of transcription, DNA-templated [IBA]
- response to drug [IEP]
- response to glucocorticoid [ISO]
- response to glucose [IEP]
- response to heat [IEP]
- response to insulin [IEP]
- response to interferon-gamma [IMP]
- response to lipopolysaccharide [IEP]
Gene Ontology Molecular Function- 5S rRNA binding [IDA]
- DNA binding, bending [IDA, ISO]
- RAGE receptor binding [IMP, IPI]
- bent DNA binding [IDA]
- calcium-dependent protein kinase regulator activity [ISO]
- chromatin binding [IBA]
- crossed form four-way junction DNA binding [IDA]
- cytokine activity [IDA, ISO]
- double-stranded DNA binding [IDA]
- four-way junction DNA binding [IDA]
- glycolipid binding [IDA]
- heparin binding [IDA, TAS]
- open form four-way junction DNA binding [IDA]
- peptide binding [IDA]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein dimerization activity [IDA]
- protein kinase activator activity [ISO]
- repressing transcription factor binding [ISO]
- sequence-specific DNA binding transcription factor activity [ISO]
- single-stranded DNA binding [IDA]
- transcription factor binding [IDA, ISO]
- 5S rRNA binding [IDA]
- DNA binding, bending [IDA, ISO]
- RAGE receptor binding [IMP, IPI]
- bent DNA binding [IDA]
- calcium-dependent protein kinase regulator activity [ISO]
- chromatin binding [IBA]
- crossed form four-way junction DNA binding [IDA]
- cytokine activity [IDA, ISO]
- double-stranded DNA binding [IDA]
- four-way junction DNA binding [IDA]
- glycolipid binding [IDA]
- heparin binding [IDA, TAS]
- open form four-way junction DNA binding [IDA]
- peptide binding [IDA]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein dimerization activity [IDA]
- protein kinase activator activity [ISO]
- repressing transcription factor binding [ISO]
- sequence-specific DNA binding transcription factor activity [ISO]
- single-stranded DNA binding [IDA]
- transcription factor binding [IDA, ISO]
Gene Ontology Cellular Component
Rattus norvegicus
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Phosphorylation of HMG-I by protein kinase C attenuates its binding affinity to the promoter regions of protein kinase C gamma and neurogranin/RC3 genes.
A 20-kDa DNA-binding protein that binds the AT-rich sequences within the promoters of the brain-specific protein kinase C (PKC) gamma and neurogranin/RC3 genes has been characterized as chromosomal nonhistone high-mobility-group protein (HMG)-I. This protein is a substrate of PKC alpha, beta, gamma, and delta but is poorly phosphorylated by PKC epsilon and zeta. Two major (Ser44 and Ser64) and four ... [more]
J. Neurochem. Jan. 01, 2000; 74(1);392-9 [Pubmed: 10617144]
Throughput
- Low Throughput
Curated By
- BioGRID