HDAC9
Gene Ontology Biological Process
- B cell activation [TAS]
- B cell differentiation [TAS]
- Notch signaling pathway [TAS]
- cellular response to insulin stimulus [IDA]
- heart development [ISS]
- histone H3 deacetylation [IDA]
- histone H4 deacetylation [IDA]
- histone deacetylation [IDA]
- inflammatory response [TAS]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- peptidyl-lysine deacetylation [IDA]
- positive regulation of cell migration involved in sprouting angiogenesis [IMP]
- regulation of skeletal muscle fiber development [ISS]
- regulation of striated muscle cell differentiation [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
YWHAE
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [TAS]
- apoptotic process [TAS]
- apoptotic signaling pathway [TAS]
- hippo signaling [TAS]
- intracellular signal transduction [TAS]
- intrinsic apoptotic signaling pathway [TAS]
- membrane organization [TAS]
- membrane repolarization during cardiac muscle cell action potential [IC]
- mitotic cell cycle [TAS]
- negative regulation of peptidyl-serine dephosphorylation [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [TAS]
- regulation of cysteine-type endopeptidase activity involved in apoptotic process [TAS]
- regulation of heart rate by cardiac conduction [IC]
- regulation of heart rate by hormone [NAS]
- regulation of membrane repolarization [IDA]
- regulation of potassium ion transmembrane transporter activity [IDA]
- substantia nigra development [IEP]
Gene Ontology Molecular Function- MHC class II protein complex binding [IDA]
- enzyme binding [IPI]
- histone deacetylase binding [IPI]
- ion channel binding [IPI]
- phosphoprotein binding [IPI]
- phosphoserine binding [IPI]
- poly(A) RNA binding [IDA]
- potassium channel regulator activity [IDA]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- MHC class II protein complex binding [IDA]
- enzyme binding [IPI]
- histone deacetylase binding [IPI]
- ion channel binding [IPI]
- phosphoprotein binding [IPI]
- phosphoserine binding [IPI]
- poly(A) RNA binding [IDA]
- potassium channel regulator activity [IDA]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Phosphorylation of the histone deacetylase 7 modulates its stability and association with 14-3-3 proteins.
Class II histone deacetylases (HDACs) play a role in myogenesis and inhibit transcriptional activation by myocyte enhancer factors 2. A distinct feature of class II HDACs is their ability to shuttle between the nucleus and the cytoplasm in a cell type- and signal-dependent manner. We demonstrate here that treatment with the 26 S proteosome inhibitors, MG132 and ALLN, leads to ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| YWHAE HDAC9 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | - |
Curated By
- BioGRID