CYP2E1
Gene Ontology Biological Process
- drug metabolic process [ISO]
- epoxygenase P450 pathway [IBA]
- exogenous drug catabolic process [IBA]
- heterocycle metabolic process [ISO]
- monoterpenoid metabolic process [ISO]
- oxidation-reduction process [IDA, ISO]
- response to drug [IEP]
- response to ethanol [IEP]
- response to organonitrogen compound [IEP]
- response to ozone [IEP]
- steroid metabolic process [ISO]
- triglyceride metabolic process [IMP]
- xenobiotic metabolic process [IMP, NAS]
Gene Ontology Molecular Function- FMN binding [IC]
- arachidonic acid epoxygenase activity [IBA]
- enzyme binding [ISO]
- heme binding [IBA, ISO, ISS]
- monooxygenase activity [ISO, TAS]
- oxidoreductase activity [ISO]
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [IDA]
- oxygen binding [IBA]
- steroid hydroxylase activity [IBA]
- FMN binding [IC]
- arachidonic acid epoxygenase activity [IBA]
- enzyme binding [ISO]
- heme binding [IBA, ISO, ISS]
- monooxygenase activity [ISO, TAS]
- oxidoreductase activity [ISO]
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [IDA]
- oxygen binding [IBA]
- steroid hydroxylase activity [IBA]
Gene Ontology Cellular Component
HSP90AA1
Gene Ontology Biological Process
- ATP catabolic process [ISO]
- cardiac muscle cell apoptotic process [IEP]
- chaperone-mediated protein complex assembly [ISO]
- neuron migration [IMP]
- positive regulation of cardiac muscle contraction [IEP]
- positive regulation of cell size [IMP]
- positive regulation of lamellipodium assembly [IMP]
- positive regulation of nitric oxide biosynthetic process [ISO, ISS]
- positive regulation of protein import into nucleus, translocation [IMP]
- protein folding [TAS]
- protein import into mitochondrial outer membrane [ISO]
- regulation of catalytic activity [ISO, ISS]
- response to estrogen [IEP]
- response to heat [IEP]
- response to salt stress [IEP]
- skeletal muscle contraction [IEP]
Gene Ontology Molecular Function- ATP binding [IDA]
- ATPase activity [ISO]
- CTP binding [IDA]
- GTP binding [IDA]
- MHC class II protein complex binding [ISO]
- Rho GDP-dissociation inhibitor binding [IDA]
- TPR domain binding [ISO, ISS]
- UTP binding [IDA]
- dATP binding [IDA]
- identical protein binding [ISO]
- ion channel binding [IPI]
- mRNA binding [IDA]
- nitric-oxide synthase regulator activity [ISO, ISS]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein kinase binding [IPI]
- protein phosphatase binding [IPI]
- sulfonylurea receptor binding [IPI]
- unfolded protein binding [TAS]
- ATP binding [IDA]
- ATPase activity [ISO]
- CTP binding [IDA]
- GTP binding [IDA]
- MHC class II protein complex binding [ISO]
- Rho GDP-dissociation inhibitor binding [IDA]
- TPR domain binding [ISO, ISS]
- UTP binding [IDA]
- dATP binding [IDA]
- identical protein binding [ISO]
- ion channel binding [IPI]
- mRNA binding [IDA]
- nitric-oxide synthase regulator activity [ISO, ISS]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein kinase binding [IPI]
- protein phosphatase binding [IPI]
- sulfonylurea receptor binding [IPI]
- unfolded protein binding [TAS]
Gene Ontology Cellular Component
- apical plasma membrane [IDA]
- basolateral plasma membrane [IDA]
- brush border membrane [IDA]
- cell surface [IDA]
- cytoplasm [IDA, ISO]
- cytosol [IDA, ISO]
- extracellular matrix [IDA]
- extracellular vesicular exosome [ISO]
- intracellular [ISO]
- membrane [ISO]
- mitochondrion [ISO]
- myelin sheath [ISO]
- neuron projection [IDA]
- neuronal cell body [IDA]
- nucleoplasm [ISO]
- nucleus [ISO]
- perinuclear region of cytoplasm [IDA]
- protein complex [IDA]
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Mitochondrial targeting of cytochrome P450 proteins containing NH2-terminal chimeric signals involves an unusual TOM20/TOM22 bypass mechanism.
Previously we showed that xenobiotic inducible cytochrome P450 (CYP) proteins are bimodally targeted to the endoplasmic reticulum and mitochondria. In this study, we investigated the mechanism of delivery of chimeric signal containing CYP proteins to the peripheral and channel-forming mitochondrial outer membrane translocases (TOMs). CYP+33/1A1 and CYP2B1 did not require peripheral TOM70, TOM20, or TOM22 for translocation through the channel-forming ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID