CYP2E1
Gene Ontology Biological Process
- drug metabolic process [ISO]
- epoxygenase P450 pathway [IBA]
- exogenous drug catabolic process [IBA]
- heterocycle metabolic process [ISO]
- monoterpenoid metabolic process [ISO]
- oxidation-reduction process [IDA, ISO]
- response to drug [IEP]
- response to ethanol [IEP]
- response to organonitrogen compound [IEP]
- response to ozone [IEP]
- steroid metabolic process [ISO]
- triglyceride metabolic process [IMP]
- xenobiotic metabolic process [IMP, NAS]
Gene Ontology Molecular Function- FMN binding [IC]
- arachidonic acid epoxygenase activity [IBA]
- enzyme binding [ISO]
- heme binding [IBA, ISO, ISS]
- monooxygenase activity [ISO, TAS]
- oxidoreductase activity [ISO]
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [IDA]
- oxygen binding [IBA]
- steroid hydroxylase activity [IBA]
- FMN binding [IC]
- arachidonic acid epoxygenase activity [IBA]
- enzyme binding [ISO]
- heme binding [IBA, ISO, ISS]
- monooxygenase activity [ISO, TAS]
- oxidoreductase activity [ISO]
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [IDA]
- oxygen binding [IBA]
- steroid hydroxylase activity [IBA]
Gene Ontology Cellular Component
HSPA4
Gene Ontology Biological Process
- chaperone-mediated protein complex assembly [ISO]
- kidney development [IEP]
- negative regulation of DNA binding [IMP]
- negative regulation of apoptotic process [IEP, IMP]
- negative regulation of cell death [IMP]
- negative regulation of gene expression [IMP]
- negative regulation of protein phosphorylation [IMP]
- positive regulation of angiogenesis [IEP]
- positive regulation of gene expression [IMP]
- positive regulation of protein binding [IDA]
- protein import into mitochondrial outer membrane [ISO]
- response to heat [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Mitochondrial targeting of cytochrome P450 proteins containing NH2-terminal chimeric signals involves an unusual TOM20/TOM22 bypass mechanism.
Previously we showed that xenobiotic inducible cytochrome P450 (CYP) proteins are bimodally targeted to the endoplasmic reticulum and mitochondria. In this study, we investigated the mechanism of delivery of chimeric signal containing CYP proteins to the peripheral and channel-forming mitochondrial outer membrane translocases (TOMs). CYP+33/1A1 and CYP2B1 did not require peripheral TOM70, TOM20, or TOM22 for translocation through the channel-forming ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID