BAIT
CYP2E1
Cyp2e
cytochrome P450, family 2, subfamily e, polypeptide 1
GO Process (13)
GO Function (9)
GO Component (5)
Gene Ontology Biological Process
- drug metabolic process [ISO]
- epoxygenase P450 pathway [IBA]
- exogenous drug catabolic process [IBA]
- heterocycle metabolic process [ISO]
- monoterpenoid metabolic process [ISO]
- oxidation-reduction process [IDA, ISO]
- response to drug [IEP]
- response to ethanol [IEP]
- response to organonitrogen compound [IEP]
- response to ozone [IEP]
- steroid metabolic process [ISO]
- triglyceride metabolic process [IMP]
- xenobiotic metabolic process [IMP, NAS]
Gene Ontology Molecular Function- FMN binding [IC]
- arachidonic acid epoxygenase activity [IBA]
- enzyme binding [ISO]
- heme binding [IBA, ISO, ISS]
- monooxygenase activity [ISO, TAS]
- oxidoreductase activity [ISO]
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [IDA]
- oxygen binding [IBA]
- steroid hydroxylase activity [IBA]
- FMN binding [IC]
- arachidonic acid epoxygenase activity [IBA]
- enzyme binding [ISO]
- heme binding [IBA, ISO, ISS]
- monooxygenase activity [ISO, TAS]
- oxidoreductase activity [ISO]
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [IDA]
- oxygen binding [IBA]
- steroid hydroxylase activity [IBA]
Gene Ontology Cellular Component
Rattus norvegicus
PREY
HSPA4
Hsp110, Hsp70, irp94
heat shock protein 4
GO Process (12)
GO Function (4)
GO Component (6)
Gene Ontology Biological Process
- chaperone-mediated protein complex assembly [ISO]
- kidney development [IEP]
- negative regulation of DNA binding [IMP]
- negative regulation of apoptotic process [IEP, IMP]
- negative regulation of cell death [IMP]
- negative regulation of gene expression [IMP]
- negative regulation of protein phosphorylation [IMP]
- positive regulation of angiogenesis [IEP]
- positive regulation of gene expression [IMP]
- positive regulation of protein binding [IDA]
- protein import into mitochondrial outer membrane [ISO]
- response to heat [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Mitochondrial targeting of cytochrome P450 proteins containing NH2-terminal chimeric signals involves an unusual TOM20/TOM22 bypass mechanism.
Previously we showed that xenobiotic inducible cytochrome P450 (CYP) proteins are bimodally targeted to the endoplasmic reticulum and mitochondria. In this study, we investigated the mechanism of delivery of chimeric signal containing CYP proteins to the peripheral and channel-forming mitochondrial outer membrane translocases (TOMs). CYP+33/1A1 and CYP2B1 did not require peripheral TOM70, TOM20, or TOM22 for translocation through the channel-forming ... [more]
J. Biol. Chem. Jun. 19, 2009; 284(25);17352-63 [Pubmed: 19401463]
Throughput
- Low Throughput
Curated By
- BioGRID