BAIT
CYP1A1
AHH, AHRR, CP11, CYP1, Cyp45c, Cypc45c, P-450MC, P1-450, P450-C, P450DX
cytochrome P450, family 1, subfamily a, polypeptide 1
GO Process (42)
GO Function (11)
GO Component (3)
Gene Ontology Biological Process
- 9-cis-retinoic acid biosynthetic process [IDA]
- aging [IEP]
- amine metabolic process [ISO]
- camera-type eye development [IEP]
- cell proliferation [IEP]
- cellular response to organic cyclic compound [ISO]
- coumarin metabolic process [IDA]
- demethylation [IDA]
- developmental process [IEP]
- dibenzo-p-dioxin catabolic process [IDA, IMP]
- dibenzo-p-dioxin metabolic process [IDA, ISO]
- digestive tract development [IEP]
- drug metabolic process [ISO]
- embryo development ending in birth or egg hatching [IEP]
- flavonoid metabolic process [IDA]
- hepatocyte differentiation [IEP]
- heterocycle metabolic process [ISO]
- hydrogen peroxide biosynthetic process [ISO]
- insecticide metabolic process [IDA]
- liver development [IEP]
- maternal process involved in parturition [IEP]
- oxidation-reduction process [ISO]
- porphyrin-containing compound metabolic process [IDA]
- positive regulation of G1/S transition of mitotic cell cycle [IDA]
- response to antibiotic [IEP]
- response to arsenic-containing substance [IEP]
- response to drug [IEP]
- response to food [IEP]
- response to herbicide [IEP]
- response to hyperoxia [IEP]
- response to hypoxia [IEP]
- response to immobilization stress [IEP]
- response to iron(III) ion [IEP]
- response to lipopolysaccharide [IEP]
- response to nematode [IEP]
- response to organic cyclic compound [IEP]
- response to organic substance [IEP]
- response to toxic substance [ISO]
- response to virus [IEP]
- response to vitamin A [IEP]
- response to wounding [IEP]
- toxin metabolic process [ISO]
Gene Ontology Molecular Function- catalytic activity [IDA]
- demethylase activity [IDA]
- enzyme binding [IDA, IPI]
- flavonoid 3'-monooxygenase activity [IDA]
- monooxygenase activity [IDA, ISO]
- oxidoreductase activity [IDA, ISO]
- oxidoreductase activity, acting on diphenols and related substances as donors [IDA]
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [ISO]
- protein binding [IPI]
- steroid hydroxylase activity [IDA]
- vitamin D 24-hydroxylase activity [ISO]
- catalytic activity [IDA]
- demethylase activity [IDA]
- enzyme binding [IDA, IPI]
- flavonoid 3'-monooxygenase activity [IDA]
- monooxygenase activity [IDA, ISO]
- oxidoreductase activity [IDA, ISO]
- oxidoreductase activity, acting on diphenols and related substances as donors [IDA]
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [ISO]
- protein binding [IPI]
- steroid hydroxylase activity [IDA]
- vitamin D 24-hydroxylase activity [ISO]
Gene Ontology Cellular Component
Rattus norvegicus
PREY
HSP90AA1
Hsp86, Hsp90, Hspca
heat shock protein 90, alpha (cytosolic), class A member 1
GO Process (16)
GO Function (20)
GO Component (18)
Gene Ontology Biological Process
- ATP catabolic process [ISO]
- cardiac muscle cell apoptotic process [IEP]
- chaperone-mediated protein complex assembly [ISO]
- neuron migration [IMP]
- positive regulation of cardiac muscle contraction [IEP]
- positive regulation of cell size [IMP]
- positive regulation of lamellipodium assembly [IMP]
- positive regulation of nitric oxide biosynthetic process [ISO, ISS]
- positive regulation of protein import into nucleus, translocation [IMP]
- protein folding [TAS]
- protein import into mitochondrial outer membrane [ISO]
- regulation of catalytic activity [ISO, ISS]
- response to estrogen [IEP]
- response to heat [IEP]
- response to salt stress [IEP]
- skeletal muscle contraction [IEP]
Gene Ontology Molecular Function- ATP binding [IDA]
- ATPase activity [ISO]
- CTP binding [IDA]
- GTP binding [IDA]
- MHC class II protein complex binding [ISO]
- Rho GDP-dissociation inhibitor binding [IDA]
- TPR domain binding [ISO, ISS]
- UTP binding [IDA]
- dATP binding [IDA]
- identical protein binding [ISO]
- ion channel binding [IPI]
- mRNA binding [IDA]
- nitric-oxide synthase regulator activity [ISO, ISS]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein kinase binding [IPI]
- protein phosphatase binding [IPI]
- sulfonylurea receptor binding [IPI]
- unfolded protein binding [TAS]
- ATP binding [IDA]
- ATPase activity [ISO]
- CTP binding [IDA]
- GTP binding [IDA]
- MHC class II protein complex binding [ISO]
- Rho GDP-dissociation inhibitor binding [IDA]
- TPR domain binding [ISO, ISS]
- UTP binding [IDA]
- dATP binding [IDA]
- identical protein binding [ISO]
- ion channel binding [IPI]
- mRNA binding [IDA]
- nitric-oxide synthase regulator activity [ISO, ISS]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein kinase binding [IPI]
- protein phosphatase binding [IPI]
- sulfonylurea receptor binding [IPI]
- unfolded protein binding [TAS]
Gene Ontology Cellular Component
- apical plasma membrane [IDA]
- basolateral plasma membrane [IDA]
- brush border membrane [IDA]
- cell surface [IDA]
- cytoplasm [IDA, ISO]
- cytosol [IDA, ISO]
- extracellular matrix [IDA]
- extracellular vesicular exosome [ISO]
- intracellular [ISO]
- membrane [ISO]
- mitochondrion [ISO]
- myelin sheath [ISO]
- neuron projection [IDA]
- neuronal cell body [IDA]
- nucleoplasm [ISO]
- nucleus [ISO]
- perinuclear region of cytoplasm [IDA]
- protein complex [IDA]
Rattus norvegicus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Mitochondrial targeting of cytochrome P450 proteins containing NH2-terminal chimeric signals involves an unusual TOM20/TOM22 bypass mechanism.
Previously we showed that xenobiotic inducible cytochrome P450 (CYP) proteins are bimodally targeted to the endoplasmic reticulum and mitochondria. In this study, we investigated the mechanism of delivery of chimeric signal containing CYP proteins to the peripheral and channel-forming mitochondrial outer membrane translocases (TOMs). CYP+33/1A1 and CYP2B1 did not require peripheral TOM70, TOM20, or TOM22 for translocation through the channel-forming ... [more]
J. Biol. Chem. Jun. 19, 2009; 284(25);17352-63 [Pubmed: 19401463]
Throughput
- Low Throughput
Curated By
- BioGRID