CYP1A1
Gene Ontology Biological Process
- 9-cis-retinoic acid biosynthetic process [IDA]
- aging [IEP]
- amine metabolic process [ISO]
- camera-type eye development [IEP]
- cell proliferation [IEP]
- cellular response to organic cyclic compound [ISO]
- coumarin metabolic process [IDA]
- demethylation [IDA]
- developmental process [IEP]
- dibenzo-p-dioxin catabolic process [IDA, IMP]
- dibenzo-p-dioxin metabolic process [IDA, ISO]
- digestive tract development [IEP]
- drug metabolic process [ISO]
- embryo development ending in birth or egg hatching [IEP]
- flavonoid metabolic process [IDA]
- hepatocyte differentiation [IEP]
- heterocycle metabolic process [ISO]
- hydrogen peroxide biosynthetic process [ISO]
- insecticide metabolic process [IDA]
- liver development [IEP]
- maternal process involved in parturition [IEP]
- oxidation-reduction process [ISO]
- porphyrin-containing compound metabolic process [IDA]
- positive regulation of G1/S transition of mitotic cell cycle [IDA]
- response to antibiotic [IEP]
- response to arsenic-containing substance [IEP]
- response to drug [IEP]
- response to food [IEP]
- response to herbicide [IEP]
- response to hyperoxia [IEP]
- response to hypoxia [IEP]
- response to immobilization stress [IEP]
- response to iron(III) ion [IEP]
- response to lipopolysaccharide [IEP]
- response to nematode [IEP]
- response to organic cyclic compound [IEP]
- response to organic substance [IEP]
- response to toxic substance [ISO]
- response to virus [IEP]
- response to vitamin A [IEP]
- response to wounding [IEP]
- toxin metabolic process [ISO]
Gene Ontology Molecular Function- catalytic activity [IDA]
- demethylase activity [IDA]
- enzyme binding [IDA, IPI]
- flavonoid 3'-monooxygenase activity [IDA]
- monooxygenase activity [IDA, ISO]
- oxidoreductase activity [IDA, ISO]
- oxidoreductase activity, acting on diphenols and related substances as donors [IDA]
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [ISO]
- protein binding [IPI]
- steroid hydroxylase activity [IDA]
- vitamin D 24-hydroxylase activity [ISO]
- catalytic activity [IDA]
- demethylase activity [IDA]
- enzyme binding [IDA, IPI]
- flavonoid 3'-monooxygenase activity [IDA]
- monooxygenase activity [IDA, ISO]
- oxidoreductase activity [IDA, ISO]
- oxidoreductase activity, acting on diphenols and related substances as donors [IDA]
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [ISO]
- protein binding [IPI]
- steroid hydroxylase activity [IDA]
- vitamin D 24-hydroxylase activity [ISO]
Gene Ontology Cellular Component
HSPA4
Gene Ontology Biological Process
- chaperone-mediated protein complex assembly [ISO]
- kidney development [IEP]
- negative regulation of DNA binding [IMP]
- negative regulation of apoptotic process [IEP, IMP]
- negative regulation of cell death [IMP]
- negative regulation of gene expression [IMP]
- negative regulation of protein phosphorylation [IMP]
- positive regulation of angiogenesis [IEP]
- positive regulation of gene expression [IMP]
- positive regulation of protein binding [IDA]
- protein import into mitochondrial outer membrane [ISO]
- response to heat [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Mitochondrial targeting of cytochrome P450 proteins containing NH2-terminal chimeric signals involves an unusual TOM20/TOM22 bypass mechanism.
Previously we showed that xenobiotic inducible cytochrome P450 (CYP) proteins are bimodally targeted to the endoplasmic reticulum and mitochondria. In this study, we investigated the mechanism of delivery of chimeric signal containing CYP proteins to the peripheral and channel-forming mitochondrial outer membrane translocases (TOMs). CYP+33/1A1 and CYP2B1 did not require peripheral TOM70, TOM20, or TOM22 for translocation through the channel-forming ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID