BAIT

HIST2H2AC

H2A, H2A-GL101, H2A/q, H2AFQ
histone cluster 2, H2ac
GO Process (0)
GO Function (0)
GO Component (2)

Gene Ontology Cellular Component

Homo sapiens
PREY

ANP32A

C15orf1, HPPCn, I1PP2A, LANP, MAPM, PHAP1, PHAPI, PP32
acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
Alzheimer's Disease Project
Autism spectrum disorder (ASD) Project
Homo sapiens

Reconstituted Complex

An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.

Publication

A signaling role of histone-binding proteins and INHAT subunits pp32 and Set/TAF-Ibeta in integrating chromatin hypoacetylation and transcriptional repression.

Kutney SN, Hong R, Macfarlan T, Chakravarti D

Various post-translational modifications of histones significantly influence gene transcription. Although un- or hypoacetylated histones are tightly linked to transcriptional repression, the mechanisms and identities of chromatin signal transducer proteins integrating histone hypoacetylation into repression in humans have remained largely unknown. Here we show that the mammalian histone-binding proteins and inhibitor of acetyltransferases (INHAT) complex subunits, Set/template-activating factor-Ibeta (TAF-Ibeta) and pp32, ... [more]

J. Biol. Chem. Jul. 16, 2004; 279(29);30850-5 [Pubmed: 15136563]

Throughput

  • Low Throughput

Curated By

  • BioGRID