SUV39H1
Gene Ontology Biological Process
- cellular response to DNA damage stimulus [IDA]
- cellular response to hypoxia [IDA]
- chromatin organization [TAS]
- chromatin silencing at rDNA [IDA]
- histone H3-K9 dimethylation [ISS]
- histone H3-K9 trimethylation [ISS]
- negative regulation of circadian rhythm [ISS]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of transcription, DNA-templated [ISS]
Gene Ontology Molecular Function- S-adenosylmethionine-dependent methyltransferase activity [IDA]
- chromatin binding [TAS]
- histone methyltransferase activity [IDA]
- histone methyltransferase activity (H3-K9 specific) [IDA]
- histone-lysine N-methyltransferase activity [IDA]
- protein N-terminus binding [IPI]
- protein binding [IPI]
- transcription regulatory region sequence-specific DNA binding [ISS]
- S-adenosylmethionine-dependent methyltransferase activity [IDA]
- chromatin binding [TAS]
- histone methyltransferase activity [IDA]
- histone methyltransferase activity (H3-K9 specific) [IDA]
- histone-lysine N-methyltransferase activity [IDA]
- protein N-terminus binding [IPI]
- protein binding [IPI]
- transcription regulatory region sequence-specific DNA binding [ISS]
Gene Ontology Cellular Component
SMAD5
Gene Ontology Biological Process
- BMP signaling pathway [ISS, TAS]
- cellular response to BMP stimulus [ISS]
- embryonic pattern specification [ISS]
- intracellular signal transduction [NAS, TAS]
- positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus [ISS]
- positive regulation of transcription, DNA-templated [NAS]
- signal transduction [NAS]
- transforming growth factor beta receptor signaling pathway [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Suv39h histone methyltransferases interact with Smads and cooperate in BMP-induced repression.
Smad proteins transduce signals from transforming growth factor-beta (TGF-beta) superfamily ligands to regulate the expression of target genes. In order to identify novel partners of Smad proteins in transcriptional regulation, we performed a two-hybrid screen using Smad5, a protein that is activated predominantly by bone morphogenetic protein (BMP) signaling. We identified an interaction between Smad5 and suppressor of variegation 3-9 ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID