RUNX2
Gene Ontology Biological Process
- BMP signaling pathway [IMP]
- T cell differentiation [IDA]
- cell maturation [IGI, IMP]
- cellular response to BMP stimulus [IMP]
- chondrocyte development [IMP]
- chondrocyte differentiation [IGI, IMP]
- embryonic cranial skeleton morphogenesis [IGI]
- embryonic forelimb morphogenesis [IMP]
- endochondral ossification [IMP]
- negative regulation of smoothened signaling pathway [IMP]
- negative regulation of transcription, DNA-templated [IDA, ISO]
- odontogenesis of dentin-containing tooth [IMP]
- osteoblast development [IGI]
- osteoblast differentiation [IGI, IMP]
- osteoblast fate commitment [IGI]
- positive regulation of cell proliferation [IGI, IMP]
- positive regulation of chondrocyte differentiation [IMP]
- positive regulation of gene expression [IDA]
- positive regulation of ossification [ISO]
- positive regulation of osteoblast differentiation [IDA, IGI]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI]
- positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus [IMP]
- positive regulation of transcription, DNA-templated [IDA, ISO]
- regulation of fibroblast growth factor receptor signaling pathway [IMP]
- regulation of odontogenesis of dentin-containing tooth [IMP]
- regulation of ossification [IMP]
- regulation of osteoblast differentiation [IDA]
- regulation of transcription, DNA-templated [TAS]
- skeletal system development [IMP]
- skeletal system morphogenesis [IMP]
- stem cell differentiation [IDA]
- transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function- DNA binding [IDA, IGI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- bHLH transcription factor binding [IPI]
- chromatin binding [IDA]
- histone deacetylase binding [ISO]
- protein binding [IPI]
- protein domain specific binding [IPI]
- repressing transcription factor binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA, TAS]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [IDA]
- DNA binding [IDA, IGI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- bHLH transcription factor binding [IPI]
- chromatin binding [IDA]
- histone deacetylase binding [ISO]
- protein binding [IPI]
- protein domain specific binding [IPI]
- repressing transcription factor binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA, TAS]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [IDA]
Gene Ontology Cellular Component
MSX2
Gene Ontology Biological Process
- BMP signaling pathway [IDA, IGI]
- BMP signaling pathway involved in heart development [IGI]
- activation of meiosis [IPI]
- anagen [IMP]
- anterior/posterior pattern specification [IGI]
- bone morphogenesis [IGI]
- bone trabecula formation [IMP]
- branching involved in mammary gland duct morphogenesis [IMP]
- cartilage development [IMP, ISO]
- cellular response to estradiol stimulus [IDA]
- cellular response to growth factor stimulus [IDA]
- chondrocyte development [IMP]
- embryonic digit morphogenesis [IGI]
- embryonic forelimb morphogenesis [IGI]
- embryonic hindlimb morphogenesis [IGI]
- embryonic limb morphogenesis [IGI]
- embryonic nail plate morphogenesis [IGI]
- enamel mineralization [IMP]
- endochondral bone growth [IMP]
- epithelial to mesenchymal transition involved in endocardial cushion formation [IGI]
- frontal suture morphogenesis [IMP]
- mammary gland epithelium development [IGI]
- negative regulation of CREB transcription factor activity [IDA]
- negative regulation of apoptotic process [IGI]
- negative regulation of cell proliferation [IGI]
- negative regulation of fat cell differentiation [IDA]
- negative regulation of keratinocyte differentiation [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP]
- negative regulation of transcription regulatory region DNA binding [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- odontogenesis [IMP]
- ossification [IMP]
- osteoblast development [IMP]
- osteoblast differentiation [IDA]
- outflow tract morphogenesis [IGI]
- outflow tract septum morphogenesis [IGI]
- positive regulation of BMP signaling pathway [IGI]
- positive regulation of apoptotic process [ISO]
- positive regulation of catagen [IMP]
- positive regulation of mesenchymal cell apoptotic process [IGI]
- positive regulation of osteoblast differentiation [IDA]
- regulation of apoptotic process [IDA]
- regulation of transcription from RNA polymerase II promoter [ISO]
- signal transduction involved in regulation of gene expression [IGI]
- stem cell differentiation [IGI]
- transcription from RNA polymerase II promoter [IMP, ISO]
- wound healing [IMP]
- wound healing, spreading of epidermal cells [IMP]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity [ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [IMP]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA, IMP]
- protein binding [IPI]
- sequence-specific DNA binding [ISO]
- transcription cofactor activity [IDA]
- transcription factor binding [IPI]
- transcription factor binding transcription factor activity [IDA]
- transcription regulatory region DNA binding [IDA]
- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity [ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [IMP]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA, IMP]
- protein binding [IPI]
- sequence-specific DNA binding [ISO]
- transcription cofactor activity [IDA]
- transcription factor binding [IPI]
- transcription factor binding transcription factor activity [IDA]
- transcription regulatory region DNA binding [IDA]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Homeobox protein MSX2 acts as a molecular defense mechanism for preventing ossification in ligament fibroblasts.
Ligaments and tendons are comprised of tough yet flexible connective tissue. Little is known, however, about the precise characteristics of the cells in ligaments and tendons due to the absence of specific markers and cell lines. We recently reported a periodontal ligament cell line, PDL-L2, with suppressed Runx2/Osf2 transcriptional activity and an inability to form mineralized nodules. The present study ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| MSX2 RUNX2 | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | - |
Curated By
- BioGRID