BAIT
NCOR1
N-CoR, N-CoR1, PPP1R109, TRAC1, hN-CoR
nuclear receptor corepressor 1
GO Process (14)
GO Function (6)
GO Component (8)
Gene Ontology Biological Process
- Notch signaling pathway [TAS]
- cellular lipid metabolic process [TAS]
- gene expression [TAS]
- negative regulation of JNK cascade [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IMP, TAS]
- regulation of fatty acid transport [IC]
- regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter [IMP]
- small molecule metabolic process [TAS]
- spindle assembly [IMP]
- transcription from RNA polymerase II promoter [TAS]
- transcription initiation from RNA polymerase II promoter [TAS]
- transcription, DNA-templated [TAS]
- transforming growth factor beta receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
NR3C1
GR, Gcr, Grl
nuclear receptor subfamily 3, group C, member 1
GO Process (41)
GO Function (25)
GO Component (10)
Gene Ontology Biological Process
- adrenal gland development [ISO]
- aging [IEP]
- androgen metabolic process [IEP]
- brain development [IEP]
- cellular response to dexamethasone stimulus [IMP]
- cellular response to magnesium ion [IEP]
- cellular response to steroid hormone stimulus [ISO, ISS]
- chromatin remodeling [IMP]
- chromatin-mediated maintenance of transcription [IMP]
- circadian rhythm [IEP]
- glucocorticoid mediated signaling pathway [ISO]
- glucocorticoid metabolic process [ISO]
- glucocorticoid receptor signaling pathway [ISO]
- lung development [IEP]
- mammary gland duct morphogenesis [ISO]
- maternal behavior [ISO]
- muscle atrophy [IEP]
- negative regulation of glucocorticoid mediated signaling pathway [ISO]
- negative regulation of synaptic plasticity [IMP]
- negative regulation of vascular permeability [IMP]
- positive regulation of cell growth involved in cardiac muscle cell development [IMP]
- positive regulation of dendritic spine development [IMP]
- positive regulation of glucocorticoid receptor signaling pathway [IDA]
- positive regulation of glutamate secretion [IMP]
- positive regulation of neuron apoptotic process [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP, ISO]
- regulation of cell proliferation [IDA]
- regulation of glucocorticoid biosynthetic process [ISO]
- regulation of gluconeogenesis [ISO]
- regulation of glucose metabolic process [IMP]
- regulation of transcription, DNA-templated [ISO]
- response to activity [IEP]
- response to arsenic-containing substance [IDA]
- response to calcium ion [IEP]
- response to corticosterone [IEP]
- response to dexamethasone [IEP]
- response to electrical stimulus [IEP]
- response to inactivity [IEP]
- response to insulin [IEP]
- response to mercury ion [IEP]
- response to radiation [IEP]
Gene Ontology Molecular Function- DNA binding [ISO]
- Hsp70 protein binding [IDA]
- Hsp90 protein binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II regulatory region DNA binding [IDA]
- chromatin binding [IDA]
- double-stranded DNA binding [IDA]
- glucocorticoid receptor activity [ISO]
- glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity [ISO, ISS]
- heat shock protein binding [IDA]
- hormone binding [IPI]
- protein binding [IPI]
- protein complex binding [IDA, IPI]
- protein dimerization activity [ISO, TAS]
- protein heterodimerization activity [IDA]
- protein homodimerization activity [IDA]
- receptor tyrosine kinase binding [IPI]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [IMP, ISO, ISS]
- steroid binding [IPI, ISO]
- steroid hormone binding [ISO, ISS]
- transcription coactivator activity [IDA]
- transcription factor binding [IPI]
- zinc ion binding [TAS]
- DNA binding [ISO]
- Hsp70 protein binding [IDA]
- Hsp90 protein binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II regulatory region DNA binding [IDA]
- chromatin binding [IDA]
- double-stranded DNA binding [IDA]
- glucocorticoid receptor activity [ISO]
- glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity [ISO, ISS]
- heat shock protein binding [IDA]
- hormone binding [IPI]
- protein binding [IPI]
- protein complex binding [IDA, IPI]
- protein dimerization activity [ISO, TAS]
- protein heterodimerization activity [IDA]
- protein homodimerization activity [IDA]
- receptor tyrosine kinase binding [IPI]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [IMP, ISO, ISS]
- steroid binding [IPI, ISO]
- steroid hormone binding [ISO, ISS]
- transcription coactivator activity [IDA]
- transcription factor binding [IPI]
- zinc ion binding [TAS]
Gene Ontology Cellular Component
Rattus norvegicus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Equilibrium interactions of corepressors and coactivators with agonist and antagonist complexes of glucocorticoid receptors.
Corepressors and coactivators can modulate the dose-response curve and partial agonist activity of glucocorticoid receptors (GRs) complexed with agonist and antagonist steroids, respectively, in intact cells. We recently reported that GR-antagonist complexes bind to the coactivator TIF2, (transcriptional intermediary factor 2), which is consistent with the whole-cell effects of coactivators being mediated by direct interactions with GR complexes. We now ... [more]
Mol. Endocrinol. Jun. 01, 2004; 18(6);1376-95 [Pubmed: 15016838]
Throughput
- Low Throughput
Curated By
- BioGRID