CREBBP
Gene Ontology Biological Process
- N-terminal peptidyl-lysine acetylation [ISO]
- cell proliferation [ISO]
- germ-line stem cell maintenance [IMP]
- histone acetylation [IDA, ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of G1/S transition of mitotic cell cycle [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [TAS]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, ISO]
- positive regulation of transcription, DNA-templated [IDA, ISO]
- regulation of transcription, DNA-templated [IDA, ISO]
- transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function- DNA binding [IDA]
- MRF binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- RNA polymerase II transcription factor binding [ISO]
- RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription [ISO]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- SMAD binding [ISO]
- acetyltransferase activity [IDA, ISO]
- activating transcription factor binding [ISO]
- chromatin binding [IDA]
- core promoter proximal region sequence-specific DNA binding [ISO]
- histone acetyltransferase activity [IDA, ISO]
- p53 binding [ISO]
- peroxisome proliferator activated receptor binding [ISO]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [ISO]
- transcription coactivator activity [ISO, TAS]
- transcription factor binding [IPI, ISO]
- DNA binding [IDA]
- MRF binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- RNA polymerase II transcription factor binding [ISO]
- RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription [ISO]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- SMAD binding [ISO]
- acetyltransferase activity [IDA, ISO]
- activating transcription factor binding [ISO]
- chromatin binding [IDA]
- core promoter proximal region sequence-specific DNA binding [ISO]
- histone acetyltransferase activity [IDA, ISO]
- p53 binding [ISO]
- peroxisome proliferator activated receptor binding [ISO]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [ISO]
- transcription coactivator activity [ISO, TAS]
- transcription factor binding [IPI, ISO]
Gene Ontology Cellular Component
KAT2B
Gene Ontology Biological Process
- N-terminal peptidyl-lysine acetylation [ISO]
- cellular response to insulin stimulus [ISO]
- chromatin remodeling [ISO]
- histone H3 acetylation [ISO]
- histone H3-K9 acetylation [IGI]
- histone acetylation [IDA]
- internal peptidyl-lysine acetylation [IMP, ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of cyclin-dependent protein serine/threonine kinase activity [IDA]
- peptidyl-lysine acetylation [ISO]
- positive regulation of chromatin binding [ISO]
- positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter [IGI]
- positive regulation of histone H3-K14 acetylation [ISO]
- positive regulation of histone H3-K9 acetylation [ISO]
- positive regulation of neuron projection development [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IGI, ISO]
- positive regulation of transcription, DNA-templated [IDA]
- positive regulation of vasodilation [ISO]
- protein acetylation [ISO, TAS]
- regulation of protein ADP-ribosylation [ISO]
- regulation of transcription, DNA-templated [TAS]
Gene Ontology Molecular Function- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- acetyltransferase activity [ISO]
- chromatin binding [ISO]
- cyclin-dependent protein serine/threonine kinase inhibitor activity [IDA]
- histone acetyltransferase activity [IDA, ISO]
- histone acetyltransferase binding [ISO]
- histone deacetylase binding [ISO]
- lysine N-acetyltransferase activity, acting on acetyl phosphate as donor [IDA, ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase binding [IPI]
- transcription coactivator activity [IDA, ISO]
- transcription cofactor activity [ISO]
- transcription factor binding [ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- acetyltransferase activity [ISO]
- chromatin binding [ISO]
- cyclin-dependent protein serine/threonine kinase inhibitor activity [IDA]
- histone acetyltransferase activity [IDA, ISO]
- histone acetyltransferase binding [ISO]
- histone deacetylase binding [ISO]
- lysine N-acetyltransferase activity, acting on acetyl phosphate as donor [IDA, ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase binding [IPI]
- transcription coactivator activity [IDA, ISO]
- transcription cofactor activity [ISO]
- transcription factor binding [ISO]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Differential roles of p300 and PCAF acetyltransferases in muscle differentiation.
PCAF is a histone acetyltransferase that associates with p300/CBP and competes with E1A for access to them. While exogenous expression of PCAF potentiates both MyoD-directed transcription and myogenic differentiation, PCAF inactivation by anti-PCAF antibody microinjection prevents differentiation. MyoD interacts directly with both p300/CBP and PCAF, forming a multimeric protein complex on the promoter elements. Viral transforming factors that interfere with ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CREBBP KAT2B | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | 1108411 |
Curated By
- BioGRID