BAIT
TAF9
MGC:5067, STAF31/32, TAF2G, TAFII-31, TAFII-32, TAFII31, TAFII32, TAFIID32, AD-004
TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
GO Process (16)
GO Function (8)
GO Component (7)
Gene Ontology Biological Process
- cellular response to DNA damage stimulus [IC]
- chromatin organization [TAS]
- gene expression [TAS]
- histone H3 acetylation [IDA]
- negative regulation of apoptotic process [IMP]
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [IC]
- negative regulation of proteasomal ubiquitin-dependent protein catabolic process [IDA]
- positive regulation of cell growth [IMP]
- positive regulation of response to cytokine stimulus [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- protein stabilization [IDA]
- response to interleukin-1 [IMP]
- transcription elongation from RNA polymerase II promoter [TAS]
- transcription from RNA polymerase II promoter [TAS]
- transcription initiation from RNA polymerase II promoter [TAS]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
GTF2B
TF2B, TFIIB, RP11-82K18.1
general transcription factor IIB
GO Process (5)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
The corepressor N-CoR and its variants RIP13a and RIP13Delta1 directly interact with the basal transcription factors TFIIB, TAFII32 and TAFII70.
Repression of transcription by the classical nuclear receptors (e.g. TR, RAR), the orphan nuclear receptors (e.g. Rev-erbAalpha/beta), Mxi-1 and Mad bHLH-zip proteins and the oncoproteins PLZF and LAZ3/BCL6 is mediated by the corepressors N-CoR and SMRT. The interaction of the corepressors with the components involved in chromatin remodelling, such as the recruiting proteins Sin3A/B and the histone deacteylases HDAc-1 and ... [more]
Nucleic Acids Res. Jun. 15, 1998; 26(12);2899-907 [Pubmed: 9611234]
Throughput
- Low Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
TAF9 GTF2B | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - | |
GTF2B TAF9 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID