BAIT
NCOR1
N-CoR, N-CoR1, PPP1R109, TRAC1, hN-CoR
nuclear receptor corepressor 1
GO Process (14)
GO Function (6)
GO Component (8)
Gene Ontology Biological Process
- Notch signaling pathway [TAS]
- cellular lipid metabolic process [TAS]
- gene expression [TAS]
- negative regulation of JNK cascade [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IMP, TAS]
- regulation of fatty acid transport [IC]
- regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter [IMP]
- small molecule metabolic process [TAS]
- spindle assembly [IMP]
- transcription from RNA polymerase II promoter [TAS]
- transcription initiation from RNA polymerase II promoter [TAS]
- transcription, DNA-templated [TAS]
- transforming growth factor beta receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
TAF6
MGC:8964, TAF(II)70, TAF(II)80, TAF2E, TAFII-70, TAFII-80, TAFII70, TAFII80, TAFII85
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
GO Process (9)
GO Function (3)
GO Component (6)
Gene Ontology Biological Process
- DNA-templated transcription, initiation [IDA]
- gene expression [TAS]
- negative regulation of cell cycle [IDA]
- negative regulation of cell proliferation [IDA]
- regulation of transcription, DNA-templated [IDA]
- transcription elongation from RNA polymerase II promoter [TAS]
- transcription from RNA polymerase II promoter [NAS, TAS]
- transcription initiation from RNA polymerase II promoter [IDA, TAS]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
The corepressor N-CoR and its variants RIP13a and RIP13Delta1 directly interact with the basal transcription factors TFIIB, TAFII32 and TAFII70.
Repression of transcription by the classical nuclear receptors (e.g. TR, RAR), the orphan nuclear receptors (e.g. Rev-erbAalpha/beta), Mxi-1 and Mad bHLH-zip proteins and the oncoproteins PLZF and LAZ3/BCL6 is mediated by the corepressors N-CoR and SMRT. The interaction of the corepressors with the components involved in chromatin remodelling, such as the recruiting proteins Sin3A/B and the histone deacteylases HDAc-1 and ... [more]
Nucleic Acids Res. Jun. 15, 1998; 26(12);2899-907 [Pubmed: 9611234]
Throughput
- Low Throughput
Curated By
- BioGRID