Reconstituted Complex

An interaction is detected between purified proteins in vitro.


The corepressor N-CoR and its variants RIP13a and RIP13Delta1 directly interact with the basal transcription factors TFIIB, TAFII32 and TAFII70.

Muscat GE, Burke LJ, Downes M

Repression of transcription by the classical nuclear receptors (e.g. TR, RAR), the orphan nuclear receptors (e.g. Rev-erbAalpha/beta), Mxi-1 and Mad bHLH-zip proteins and the oncoproteins PLZF and LAZ3/BCL6 is mediated by the corepressors N-CoR and SMRT. The interaction of the corepressors with the components involved in chromatin remodelling, such as the recruiting proteins Sin3A/B and the histone deacteylases HDAc-1 and ... [more]

Nucleic Acids Res. Jun. 15, 1998; 26(12);2899-907 [Pubmed: 9611234]


  • Low Throughput

Curated By

  • BioGRID