BMI1
Gene Ontology Biological Process
- DNA methylation [IMP]
- brain development [IMP]
- cellular process [TAS]
- embryonic skeletal system development [IGI]
- embryonic skeletal system morphogenesis [IGI]
- histone acetylation [IGI]
- histone ubiquitination [IDA]
- humoral immune response [IMP]
- in utero embryonic development [IGI]
- negative regulation of apoptotic signaling pathway [IGI]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP]
- positive regulation of B cell proliferation [IMP]
- positive regulation of immature T cell proliferation in thymus [IMP]
- regulation of catalytic activity [IDA]
- rostrocaudal neural tube patterning [IMP]
- skeletal system development [IMP]
- somatic stem cell division [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CBX2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
RAE28, BMI1, and M33 are members of heterogeneous multimeric mammalian Polycomb group complexes.
The Polycomb group loci in Drosophila encode chromatin proteins required for repression of homeotic loci in embryonic development. We show that mouse Polycomb group homologues, RAE28, BMI1 and M33, have overlapping but not identical expression patterns during embryogenesis and in adult tissues. These three proteins coimmunoprecipitate from embryonic nuclear extracts. Gel filtration analysis of embryonic extracts indicates that RAE28, BMI1 ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CBX2 BMI1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| BMI1 CBX2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| BMI1 CBX2 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID