BAIT

PALB2

FANCN, PNCA3
partner and localizer of BRCA2
GO Process (2)
GO Function (2)
GO Component (1)

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Reconstituted Complex

An interaction is detected between purified proteins in vitro.

Publication

Enhancement of RAD51 recombinase activity by the tumor suppressor PALB2.

Dray E, Etchin J, Wiese C, Saro D, Williams GJ, Hammel M, Yu X, Galkin VE, Liu D, Tsai MS, Sy SM, Schild D, Egelman E, Chen J, Sung P

Homologous recombination mediated by RAD51 recombinase helps eliminate chromosomal lesions, such as DNA double-strand breaks induced by radiation or arising from injured DNA replication forks. The tumor suppressors BRCA2 and PALB2 act together to deliver RAD51 to chromosomal lesions to initiate repair. Here we document a new function of PALB2: to enhance RAD51's ability to form the D loop. We ... [more]

Nat. Struct. Mol. Biol. Oct. 01, 2010; 17(10);1255-9 [Pubmed: 20871616]

Throughput

  • Low Throughput

Curated By

  • BioGRID