BAIT

TRIM28

AA408787, KAP-1, KRIP-1, MommeD9, Tif1b, Tif1beta
tripartite motif-containing 28
GO Process (21)
GO Function (13)
GO Component (6)
Mus musculus
PREY

MYB

AI550390, M16449, c-myb
myeloblastosis oncogene
Mus musculus

Reconstituted Complex

An interaction is detected between purified proteins in vitro.

Publication

Oncogenic activation of c-Myb correlates with a loss of negative regulation by TIF1beta and Ski.

Nomura T, Tanikawa J, Akimaru H, Kanei-Ishii C, Ichikawa-Iwata E, Khan MM, Ito H, Ishii S

The c-myb proto-oncogene product (c-Myb) regulates proliferation of hematopoietic cells by inducing the transcription of a group of target genes. Removal or mutations of the negative regulatory domain (NRD) in the C-terminal half of c-Myb leads to increased transactivating capacity and oncogenic activation. Here we report that TIF1beta directly binds to the NRD and negatively regulates the c-Myb-dependent trans-activation. In ... [more]

J. Biol. Chem. Apr. 16, 2004; 279(16);16715-26 [Pubmed: 14761981]

Throughput

  • Low Throughput

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
MYB TRIM28
Two-hybrid
Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Low-BioGRID
-

Curated By

  • BioGRID