BAIT
TRIM28
AA408787, KAP-1, KRIP-1, MommeD9, Tif1b, Tif1beta
tripartite motif-containing 28
GO Process (21)
GO Function (13)
GO Component (6)
Gene Ontology Biological Process
- DNA methylation involved in embryo development [IMP]
- DNA repair [ISO]
- convergent extension involved in axis elongation [IMP]
- embryo implantation [IMP]
- embryonic placenta morphogenesis [IMP]
- epithelial to mesenchymal transition [IDA]
- in utero embryonic development [IMP]
- innate immune response [ISO]
- negative regulation of DNA demethylation [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IGI]
- negative regulation of transcription, DNA-templated [IDA, IMP, ISO]
- negative regulation of viral release from host cell [ISO]
- positive regulation of DNA repair [ISO]
- positive regulation of transcription factor import into nucleus [ISO]
- positive regulation of transcription, DNA-templated [IDA]
- protein autophosphorylation [IDA]
- protein oligomerization [ISO]
- protein phosphorylation [IDA]
- protein sumoylation [ISO]
- protein ubiquitination [ISO]
- regulation of genetic imprinting [IMP]
Gene Ontology Molecular Function- DNA binding [IDA, ISO]
- Krueppel-associated box domain binding [ISO]
- chromo shadow domain binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein kinase activity [IDA]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription coactivator activity [IDA]
- transcription corepressor activity [ISO]
- ubiquitin protein ligase binding [ISO]
- ubiquitin-protein transferase activity [ISO]
- zinc ion binding [ISO]
- DNA binding [IDA, ISO]
- Krueppel-associated box domain binding [ISO]
- chromo shadow domain binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein kinase activity [IDA]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription coactivator activity [IDA]
- transcription corepressor activity [ISO]
- ubiquitin protein ligase binding [ISO]
- ubiquitin-protein transferase activity [ISO]
- zinc ion binding [ISO]
Gene Ontology Cellular Component
Mus musculus
PREY
MYB
AI550390, M16449, c-myb
myeloblastosis oncogene
GO Process (19)
GO Function (6)
GO Component (2)
Gene Ontology Biological Process
- B cell differentiation [IMP]
- G1/S transition of mitotic cell cycle [IMP]
- calcium ion transport [IMP]
- cellular response to interleukin-6 [IDA]
- chromatin remodeling [ISO]
- embryonic digestive tract development [IMP]
- homeostasis of number of cells [IMP]
- in utero embryonic development [IMP]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- negative regulation of transcription, DNA-templated [ISO]
- positive regulation of T-helper cell differentiation [ISO]
- positive regulation of histone H3-K4 methylation [ISO]
- positive regulation of histone H3-K9 methylation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, ISO]
- positive regulation of transcription, DNA-templated [ISO]
- regulation of gene expression [IMP]
- regulation of transcription, DNA-templated [IDA, IMP]
- thymus development [IMP]
- transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA, ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- WD40-repeat domain binding [IDA]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA, IMP]
- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA, ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- WD40-repeat domain binding [IDA]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA, IMP]
Mus musculus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Oncogenic activation of c-Myb correlates with a loss of negative regulation by TIF1beta and Ski.
The c-myb proto-oncogene product (c-Myb) regulates proliferation of hematopoietic cells by inducing the transcription of a group of target genes. Removal or mutations of the negative regulatory domain (NRD) in the C-terminal half of c-Myb leads to increased transactivating capacity and oncogenic activation. Here we report that TIF1beta directly binds to the NRD and negatively regulates the c-Myb-dependent trans-activation. In ... [more]
J. Biol. Chem. Apr. 16, 2004; 279(16);16715-26 [Pubmed: 14761981]
Throughput
- Low Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
MYB TRIM28 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID